Update on Biomarkers of Hepatocellular Carcinoma

被引：117

作者：

Chaiteerakij, Roongruedee ^{[1
,2
,3
,4
]}

Addissie, Benyam D. ^{[1
,2
]}

Roberts, Lewis R. ^{[1
,2
]}

机构：

[1] Mayo Clin, Coll Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA

[2] Mayo Clin, Ctr Canc, Rochester, MN 55905 USA

[3] Chulalongkorn Univ, Fac Med, Dept Med, Bangkok 10330, Thailand

[4] King Chulalongkorn Mem Hosp, Thai Red Cross Soc, Bangkok, Thailand

来源：

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | 2015年 / 13卷 / 02期

基金：

美国国家卫生研究院;

关键词：

alpha-Fetoprotein; Liver Cancer; Prognosis; Prognostic Factor; Tumor; Early Detection; CHRONIC HEPATITIS-B; ALPHA-FETOPROTEIN MEASUREMENT; DES-GAMMA CARBOXYPROTHROMBIN; GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCUS; CARBOXY PROTHROMBIN; MASS-SPECTROMETRY; VIRUS CARRIERS; LIVER-CANCER; SERUM MARKER;

D O I：

10.1016/j.cgh.2013.10.038

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

New biomarkers of hepatocellular carcinoma (HCC) have been identified using advanced genomic, proteomic, and metabolomics technologies. These are being developed not only for use in diagnosis of HCC, but also in prediction of patient and treatment outcomes and individualization of therapy. Some HCC biomarkers are currently used in surveillance to detect early stage HCCs and reduce mortality. Further studies are needed to determine whether the recently identified HCC biomarkers can be used in clinical practice; most are only in phase 1 or 2 studies. The diagnostic and predictive abilities of biomarkers are limited by the heterogeneous nature of HCCs; there is no perfect single biomarker of this tumor. To improve performance, combinations of biomarkers (panels), or combinations of biomarkers and clinical parameters or laboratory test results, might be required. We describe recently discovered biomarkers of HCC and discuss challenges to their development and application.

引用

页码：237 / 245

页数：9

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