Characterization of cyclic peptides containing disulfide bonds

被引：6

作者：

Johnson, Mindy ^{[1
]}

Liu, Mingtao ^{[1
]}

Struble, Elaine ^{[1
]}

Hettiarachchi, Kanthi ^{[1
]}

机构：

[1] SRI Int, Biosci Div, Pharmaceut Dev Sect, Menlo Pk, CA 94025 USA

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2015年 / 109卷

基金：

美国国家卫生研究院;

关键词：

Opioid peptides; Trifluoroacetic acid; RP-HPLC; Tandem mass spectrometry; Two-dimensional NMR; MASS-SPECTROMETRY; LIQUID-CHROMATOGRAPHY; OPIOID RECEPTOR; PROTEINS PRIOR; REDUCTION; DITHIOTHREITOL; IDENTIFICATION; ANALGESICS; ANALOGS; REAGENT;

D O I：

10.1016/j.jpba.2015.01.009

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Unlike linear peptides, analysis of cyclic peptides containing disulfide bonds is not straightforward and demands indirect methods to achieve a rigorous proof of structure. Three peptides that belong to this category, p-Cl-Phe-DPDPE, DPDPE, and CTOP, were analyzed and the results are presented in this paper. The great potential of two dimensional NMR and ESI tandem mass spectrometry was harnessed during the course of peptide characterizations. A new RP-HPLC method for the analysis of trifluoroacetic acid is also presented. It is robust, simple, and efficient compared to the currently available methods. (C) 2015 Published by Elsevier B.V.

引用

页码：112 / 120

页数：9

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