A Novel Controlled Release Drug Delivery System for Multiple Drugs Based on Electrospun Nanofibers Containing Nanoparticles

被引：79
作者：
Wang, Yazhou [1 ]
Wang, Bochu [1 ]
Qiao, Weili [1 ]
Yin, Tieying [1 ]
机构：
[1] Chongqing Univ, Bioengn Coll, Minist Educ, Key Lab Biorheol Sci & Technol, Chongqing 400030, Peoples R China
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 2010年 / 99卷 / 12期
关键词：
multiple drugs; controlled release; electrospun nanofibers; nanoparticles; core-sheath structures; ELECTRICALLY FORCED JETS; POROUS STRUCTURES; POLYMER FIBERS; CORE-SHEATH; FABRICATION; HOLLOW; MODEL;
D O I：
10.1002/jps.22189
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This study describes development of a novel controlled drug release system for multiple drugs, it consisted of Chitosan nanoparticles/PCL composite electrospun nanofibers with core-sheath structures. Two model agents' rhodamine B and naproxen were successfully loaded in the core and sheath region respectively. The behavior of these two agents demonstrated a good controlled release and temporality, providing a new way to obtain program or temporality release for multiple agents. Particularly, this is potential applications in the field of tissue engineering, sutures and wound dressings. (C) 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:4805-4811, 2010
引用
收藏
页码：4805 / 4811
页数：7
相关论文
共 31 条
[1]   Preparation of fibers with nanoscaled morphologies: Electrospinning of polymer blends [J].
Bognitzki, M ;
Frese, T ;
Steinhart, M ;
Greiner, A ;
Wendorff, JH ;
Schaper, A ;
Hellwig, M .
POLYMER ENGINEERING AND SCIENCE, 2001, 41 (06) :982-989
[2]  
Caruso RA, 2001, ADV MATER, V13, P1577, DOI 10.1002/1521-4095(200110)13:20<1577::AID-ADMA1577>3.0.CO
[3]  
2-S
[4]   The role of electrospinning in the emerging field of nanomedicine [J].
Chew, S. Y. ;
Wen, Y. ;
Dzenis, Y. ;
Leong, K. W. .
CURRENT PHARMACEUTICAL DESIGN, 2006, 12 (36) :4751-4770
[5]   Experimental and theoretical investigations of porous structure formation in electrospun fibers [J].
Dayal, Pratyush ;
Liu, Jing ;
Kumar, Satish ;
Kyu, Thein .
MACROMOLECULES, 2007, 40 (21) :7689-7694
[6]   Encapsulation of Multiple Biological Compounds Within a Single Electrospun Fiber [J].
Dong, Bin ;
Smith, Meghan E. ;
Wnek, Gary E. .
SMALL, 2009, 5 (13) :1508-1512
[7]   The stretching of an electrified non-Newtonian jet: A model for electrospinning [J].
Feng, JJ .
PHYSICS OF FLUIDS, 2002, 14 (11) :3912-3926
[8]   Electrospinning and electrically forced jets. I. Stability theory [J].
Hohman, MM ;
Shin, M ;
Rutledge, G ;
Brenner, MP .
PHYSICS OF FLUIDS, 2001, 13 (08) :2201-2220
[9]   Electrospinning and electrically forced jets. II. Applications [J].
Hohman, MM ;
Shin, M ;
Rutledge, G ;
Brenner, MP .
PHYSICS OF FLUIDS, 2001, 13 (08) :2221-2236
[10]   Poly(p-xylylene) nanotubes by coating and removal of ultrathin polymer template fibers [J].
Hou, HQ ;
Jun, Z ;
Reuning, A ;
Schaper, A ;
Wendorff, JH ;
Greiner, A .
MACROMOLECULES, 2002, 35 (07) :2429-2431
1234