Rab proteins as membrane organizers

被引：2676

作者：

Zerial, M ^{[1
]}

McBride, H ^{[1
]}

机构：

[1] EMBL, Max Planck Inst Mol Cell Biol & Genet, D-69117 Heidelberg, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 02期

关键词：

D O I：

10.1038/35052055

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cellular organelles in the exocytic and endocytic pathways have a distinctive spatial distribution and communicate through an elaborate system of vesiculo-tubular transport. Rab proteins and their effectors coordinate consecutive stages of transport, such as vesicle formation, vesicle and organelle motility, and tethering of vesicles to their target compartment. These molecules are highly compartmentalized in organelle membranes, making them excellent candidates for determining transport specificity and organelle identity.

引用

页码：107 / 117

页数：11

共 106 条

[1] Rab1 recruitment of p115 into a cis-SNARE complex: Programming budding COPII vesicles for fusion [J].

Allan, BB ;

Moyer, BD ;

Balch, WE .

SCIENCE, 2000, 289 (5478) :444-448

[2] Mitotic phosphorylation of rab4 prevents binding to a specific receptor on endosome membranes [J].

Ayad, N ;

Hull, M ;

Mellman, I .

EMBO JOURNAL, 1997, 16 (15) :4497-4507

[3] Evidence for a symmetrical requirement for Rab5-GTP in in vitro endosome-endosome fusion [J].

Barbieri, MA ;

Hoffenberg, S ;

Roberts, R ;

Mukhopadhyay, A ;

Pomrehn, A ;

Dickey, BF ;

Stahl, PD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (40) :25850-25855

[4] COPII - A MEMBRANE COAT FORMED BY SEC PROTEINS THAT DRIVE VESICLE BUDDING FROM THE ENDOPLASMIC-RETICULUM [J].

BARLOWE, C ;

ORCI, L ;

YEUNG, T ;

HOSOBUCHI, M ;

HAMAMOTO, S ;

SALAMA, N ;

REXACH, MF ;

RAVAZZOLA, M ;

AMHERDT, M ;

SCHEKMAN, R .

CELL, 1994, 77 (06) :895-907

[5] Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway [J].

Blondeau, F ;

Laporte, J ;

Bodin, S ;

Superti-Furga, G ;

Payrastre, B ;

Mandel, JL .

HUMAN MOLECULAR GENETICS, 2000, 9 (15) :2223-2229

[6] THE SMALL GTPASE RAB5 FUNCTIONS AS A REGULATORY FACTOR IN THE EARLY ENDOCYTIC PATHWAY [J].

BUCCI, C ;

PARTON, RG ;

MATHER, IH ;

STUNNENBERG, H ;

SIMONS, K ;

HOFLACK, B ;

ZERIAL, M .

CELL, 1992, 70 (05) :715-728

[7] Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1) [J].

Bucci, C ;

Chiariello, M ;

Lattero, D ;

Maiorano, N ;

Bruni, CB .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 258 (03) :657-662

[8] Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains [J].

Burd, CG ;

Emr, SD .

MOLECULAR CELL, 1998, 2 (01) :157-162

[9] Novel pathways, membrane coats and PI kinase regulation in yeast lysosomal trafficking [J].

Burd, CG ;

Babst, M ;

Emr, SD .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 1998, 9 (05) :527-533

[10] A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast [J].

Burd, CG ;

Peterson, M ;

Cowles, CR ;

Emr, SD .

MOLECULAR BIOLOGY OF THE CELL, 1997, 8 (06) :1089-1104

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