Exosomes and cardiovascular cell-cell communication

被引：28

作者：

Poe, Adam J. ^{[1
]}

Knowlton, Anne A. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Davis, Dept Med, Cardiovasc Div, Mol & Cellular Cardiol, Davis, CA 95616 USA

[2] VA Med Ctr, Dept Med, Cardiol Sect, Sacramento, CA 95825 USA

[3] Univ Calif Davis, Pharmacol Dept, Davis, CA 95616 USA

来源：

EXTRACELLULAR VESICLES AND MECHANISMS OF CELL-CELL COMMUNICATION | 2018年 / 62卷 / 02期

关键词：

IMPROVES CARDIAC-FUNCTION; STEM-CELLS; EXTRACELLULAR VESICLES; MEDIATED ENDOCYTOSIS; TRANSFERRIN RECEPTOR; PROGENITOR CELLS; DENDRITIC CELLS; PATHWAY; REGENERATION; ACTIVATION;

D O I：

10.1042/EBC20170081

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exosomes have become an important player in intercellular signaling. These lipid microvesicles can stably transfer miRNA, protein, and other molecules between cells and circulate throughout the body. Exosomes are released by almost all cell types and are present in most if not all biological fluids. The biologically active cargo carried by exosomes can alter the phenotype of recipient cells. Exosomes increasingly are recognized as having an important role in the progression and treatment of cardiac disease states. Injured cardiac cells can release exosomes with important pathological effects on surrounding tissue, in addition to effecting other organs. But of equal interest is the possible benefit(s) conferred by exosomes released from stem cells for use in treatment and possible repair of cardiac damage.

引用

页码：193 / 204

页数：12

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