Lipid-polymer hybrid nanocarrier-mediated cancer therapeutics: current status and future directions

被引：35

作者：

Garg, Neeraj K. ^{[1
,2
]}

Tandel, Nikunj ^{[3
]}

Jadon, Rajesh S. ^{[4
]}

Tyagi, Rajeev K. ^{[5
,6
]}

Katare, Om P. ^{[1
]}

机构：

[1] Panjab Univ, Univ Inst Pharmaceut Sci, Chandigarh 160014, India

[2] Postgrad Inst Med Educ & Res PGIMER, Dept Endocrinol, Chandigarh 160012, India

[3] Nirma Univ Ahmedabad, Inst Sci, Ahmadabad 382481, Gujarat, India

[4] Jiwaji Univ, Sch Studies, Gwalior 474002, India

[5] Amity Univ, Amity Inst Microbial Technol, Biomed Parasitol & Nanoimmunol Lab, Noida, India

[6] Augusta Univ, Dept Periodont, Coll Dent Med, Augusta, GA 30912 USA

来源：

DRUG DISCOVERY TODAY | 2018年 / 23卷 / 09期

关键词：

COATED PLGA NANOPARTICLES; TARGETED DRUG-DELIVERY; IN-VIVO EVALUATION; LIPID/POLYMER PARTICLE ASSEMBLIES; SUSTAINED-RELEASE MICROCARRIER; BREAST-CANCER; GENE DELIVERY; TUMOR-CELLS; VITRO; METHOTREXATE;

D O I：

10.1016/j.drudis.2018.05.033

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The new generation of nanoparticles (NPs) encompass attributes of lipids and polymers and are referred to as 'lipid-polymer hybrid nanoparticles' (LPHNPs). LPHNPs have helped shed light on the mechanisms involved in targeted and non-specific drug delivery. Research has also highlighted the opportunities and challenges faced by the use of nanomedicine as personalized therapies in oncology. Here, we review the development of LPHNPs as cancer therapeutics, focusing on the methods deployed for enhancing the targeting efficiency and applications of LPHNPs.

引用

页码：1610 / 1621

页数：12

共 101 条

[1] Microemulsions mediated effective delivery of methotrexate hydrogel: more than a tour de force in psoriasis therapeutics [J].