The elevated NLR, PLR and PLT may predict the prognosis of patients with colorectal cancer: a systematic review and meta-analysis

被引：143
作者：
Zhang, Jie [1 ]
Zhang, Hong-Ying [2 ]
Li, Jia [1 ]
Shao, Xin-Yu [3 ]
Zhang, Chun-Xia [1 ]
机构：
[1] Dalian Med Univ, Dept Oncol, Affiliated Hosp 1, Dalian 116011, Peoples R China
[2] Dalian Med Univ, Dept Pathol & Forens Med, Coll Basic Med Sci, Dalian 116044, Peoples R China
[3] Dalian Med Univ, Med Oncol, Affiliated Hosp 1, Dalian 116000, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 40期
关键词：
colorectal cancer; neutrophils-to-lymphocytes ratio; platelet-to-lymphocytes ratio; platelet counts; prognosis; PLATELET-LYMPHOCYTE RATIO; POOR-PROGNOSIS; INFLAMMATORY RESPONSE; NEUTROPHIL/LYMPHOCYTE RATIO; PREOPERATIVE THROMBOCYTOSIS; NEUTROPHIL-LYMPHOCYTE; SURVIVAL; COUNT; RECURRENCE; MANAGEMENT;
D O I：
10.18632/oncotarget.18575
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recently, several studies have reported that inflammatory response and elevated platelet counts may be associated with the poor prognosis of colorectal cancer. This meta-analysis was designed to analyze and evaluate the prognostic role of elevated preoperative or pretreatment neutrophils-to-lymphocytes ratio, platelet-to-lymphocytes ratio or platelet counts in patients with colorectal cancer. We searched PubMed, EMBASE, Cochrane Library and Web of Science to April, 2016. A total of 23 studies (N = 11762 participants) were included for this meta-analysis. Elevated neutrophils-to-lymphocytes ratio have a close relationship with the poor Overall Survival of colorectal cancer with the pooled HR being 1.92 [95% CI 1.57-2.34; P < 0.00001]. This meta-analysis indicated that elevated neutrophils-to-lymphocytes ratio, platelet-to-lymphocytes ratio or platelet counts may be a cost-effective and noninvasive serum biomarker for poor prognosis for patients with colorectal cancer.
引用
收藏
页码：68837 / 68846
页数：10
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