Multicellular Vascularized Engineered Tissues through User-Programmable Biomaterial Photodegradation

被引：158

作者：

Arakawa, Christopher K. ^{[1
]}

Badeau, Barry A. ^{[2
]}

Zheng, Ying ^{[1
,3
]}

DeForest, Cole A. ^{[1
,2
,3
]}

机构：

[1] Univ Washington, Dept Bioengn, 3720 15th Ave NE, Seattle, WA 98105 USA

[2] Univ Washington, Dept Chem Engn, 3781 Okanogan Lane NE, Seattle, WA 98195 USA

[3] Univ Washington, Inst Stem Cell & Regenerat Med, 850 Republican St, Seattle, WA 98109 USA

来源：

ADVANCED MATERIALS | 2017年 / 29卷 / 37期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

biomaterials; hydrogels; photodegradation; tissue engineering; vascular engineering; CLICK-BASED HYDROGELS; STEM-CELL FATE; IN-VITRO; MICROFLUIDIC NETWORKS; ANGIOGENESIS; CONSTRUCTS; CHANNELS;

D O I：

10.1002/adma.201703156

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A photodegradable material-based approach to generate endothelialized 3D vascular networks within cell-laden hydrogel biomaterials is introduced. Exploiting multiphoton lithography, microchannel networks spanning nearly all size scales of native human vasculature are readily generated with unprecedented user-defined 4D control. Intraluminal channel architectures of synthetic vessels are fully customizable, providing new opportunities for next-generation microfluidics and directed cell function.

引用

页数：9

共 38 条

[1] Cell-microenvironment interactions and architectures in microvascular systems [J].

Bersini, Simone ;

Yazdi, Iman K. ;

Talo, Giuseppe ;

Shin, Su Ryon ;

Moretti, Matteo ;

Khademhosseini, Ali .

BIOTECHNOLOGY ADVANCES, 2016, 34 (06) :1113-1130

[2] In Situ Patterning of Microfluidic Networks in 3D Cell-Laden Hydrogels [J].

Brandenberg, Nathalie ;

Lutolf, Matthias P. .

ADVANCED MATERIALS, 2016, 28 (34) :7450-7456

[3] Mechanisms of angiogenesis and arteriogenesis [J].

Carmeliet, P .

NATURE MEDICINE, 2000, 6 (04) :389-395

[4] Synthesis of Self-assembling Cyclic Peptide-polymer Conjugates using Click Chemistry [J].

Chapman, Robert ;

Jolliffe, Katrina A. ;

Perrier, Sebastien .

AUSTRALIAN JOURNAL OF CHEMISTRY, 2010, 63 (08) :1169-1172

[5] Endothelial cells and VEGF in vascular development [J].

Coultas, L ;

Chawengsaksophak, K ;

Rossant, J .

NATURE, 2005, 438 (7070) :937-945

[6]

DeForest CA, 2015, NAT MATER, V14, P523, DOI [10.1038/NMAT4219, 10.1038/nmat4219]

[7] Photoreversible Patterning of Biomolecules within Click-Based Hydrogels [J].

DeForest, Cole A. ;

Anseth, Kristi S. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (08) :1816-1819

[8]

DeForest CA, 2011, NAT CHEM, V3, P925, DOI [10.1038/nchem.1174, 10.1038/NCHEM.1174]

[9]

DeForest CA, 2009, NAT MATER, V8, P659, DOI [10.1038/NMAT2473, 10.1038/nmat2473]

[10] Characterization of In Vitro Endothelial Linings Grown Within Microfluidic Channels [J].

Esch, Mandy B. ;

Post, David J. ;

Shuler, Michael L. ;

Stokol, Tracy .

TISSUE ENGINEERING PART A, 2011, 17 (23-24) :2965-2971

← 1 2 3 4 →