Multicellular Vascularized Engineered Tissues through User-Programmable Biomaterial Photodegradation

被引：150
作者：
Arakawa, Christopher K. [1 ]
Badeau, Barry A. [2 ]
Zheng, Ying [1 ,3 ]
DeForest, Cole A. [1 ,2 ,3 ]
机构：
[1] Univ Washington, Dept Bioengn, 3720 15th Ave NE, Seattle, WA 98105 USA
[2] Univ Washington, Dept Chem Engn, 3781 Okanogan Lane NE, Seattle, WA 98195 USA
[3] Univ Washington, Inst Stem Cell & Regenerat Med, 850 Republican St, Seattle, WA 98109 USA
来源：
ADVANCED MATERIALS | 2017年 / 29卷 / 37期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
biomaterials; hydrogels; photodegradation; tissue engineering; vascular engineering; CLICK-BASED HYDROGELS; STEM-CELL FATE; IN-VITRO; MICROFLUIDIC NETWORKS; ANGIOGENESIS; CONSTRUCTS; CHANNELS;
D O I：
10.1002/adma.201703156
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A photodegradable material-based approach to generate endothelialized 3D vascular networks within cell-laden hydrogel biomaterials is introduced. Exploiting multiphoton lithography, microchannel networks spanning nearly all size scales of native human vasculature are readily generated with unprecedented user-defined 4D control. Intraluminal channel architectures of synthetic vessels are fully customizable, providing new opportunities for next-generation microfluidics and directed cell function.
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页数：9
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