Use of calcium channel blockers for glaucoma

被引:66
作者
Araie, Makoto [1 ]
Mayama, Chihiro [1 ]
机构
[1] Univ Tokyo, Grad Sch Med, Dept Ophthalmol, Bunkyo Ku, Tokyo 1138655, Japan
关键词
L-type calcium channel; Intraocular pressure; Blood flow; Visual field; Neuroprotection; Open-angle glaucoma; OPTIC-NERVE HEAD; OPEN-ANGLE GLAUCOMA; NORMAL-TENSION GLAUCOMA; OCULAR BLOOD-FLOW; MUSCARINIC RECEPTOR ACTIVATION; LATERAL GENICULATE-NUCLEUS; CEREBRAL-ARTERY OCCLUSION; RETINAL GANGLION-CELLS; CROSS-SECTIONAL SURVEY; VISUAL-FIELD DEFECT;
D O I
10.1016/j.preteyeres.2010.09.002
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Calcium channel blockers (CCBs), which alter the intracellular calcium concentration by modifying calcium flux across cell membranes and affect various intracellular signaling processes, have been long and widely used to treat essential hypertension and certain types of cardiac diseases such as angina pectoris. Among five subtypes of calcium channels, only specific agents for L-type calcium channels have been used as therapeutics. Animal experiments have indicated that topical application of CCBs, especially verapamil, caused significant intraocular pressure (IOP) reductions, while ocular hypotensive effects in humans were not substantial. Although the results obtained for nifedipine and nimodipine were not always consistent, CCBs generally dilate isolated ocular vessels and increase ocular blood flow in experimental animals, normal humans, and patients with open-angle glaucoma (OAG). Several single-centered, hospital-based, prospective studies have suggested that nimodipine, brovincamine, and nilvadipine had beneficial effects on visual function not only in normal humans but also in patients with OAG, while the results of population-based and case-controlled studies were not always consistent with those obtained in hospital-based studies. In vitro studies showed that CCBs exerted neuroprotective effects on neurons undergoing apoptosis and necrosis. Although the neuroprotective effects of CCBs have been well documented in experimental cerebral ischemia models, no controlled studies have shown the clinical efficacy of CCBs in stroke or cerebral ischemia. Neuroprotective effects also were documented in retinal ganglion cells and photoreceptors in experimental animals. Some ophthalmic beta-adrenoceptor antagonists, especially betaxolol, interact with L-type calcium channels and show calcium channel-blocking activity, which may be partly responsible for the neuroprotective effects of these drugs reported in experimental animals. Based on the reported findings of CCBs and that the results of clinical studies in acute cerebral ischemia may not be directly applicable to a chronic neurodegenerative ocular disorder, such as OAG, CCBs deserve future study to investigate strategies that are additive or synergetic to ocular hypotensive therapy for OAG, especially in patients with lower IOP. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:54 / 71
页数:18
相关论文
共 343 条
[11]   VERAPAMIL BLOCKS BASAL AND ANGIOTENSIN-II-INDUCED RNA-SYNTHESIS OF RAT AORTIC VASCULAR SMOOTH-MUSCLE CELLS [J].
ANDRAWIS, NS ;
ABERNETHY, DR .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 183 (02) :767-773
[12]   Antiarrhythmic effects of magnesium on rat papillary muscle and guinea pig ventricular myocytes [J].
Aomine, M ;
Tatsukawa, Y ;
Yamato, T ;
Yamasaki, S .
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1999, 32 (01) :107-114
[13]   β-adrenergic receptor agonists and antagonists counteract LPS-induced neuronal death in retinal cultures by different mechanisms [J].
Arai, K ;
Wood, JPM ;
Osborne, NN .
BRAIN RESEARCH, 2003, 985 (02) :176-186
[14]   Influence of topical betaxolol and timolol on visual field in Japanese open-angle glaucoma patients [J].
Araie, M ;
Azuma, I ;
Kitazawa, Y .
JAPANESE JOURNAL OF OPHTHALMOLOGY, 2003, 47 (02) :199-207
[15]  
Araie M, 2009, OCULAR BLOOD FLOW GL, P59
[16]  
Aydin B, 2010, EUR J OPHTHALMOL, V20, P131
[17]  
Baptiste DC, 2002, INVEST OPHTH VIS SCI, V43, P2666
[18]  
BEAN BP, 1989, ANNU REV PHYSIOL, V51, P367, DOI 10.1146/annurev.physiol.51.1.367
[19]  
BEATTY JF, 1984, ARCH OPHTHALMOL-CHIC, V102, P1072
[20]   Loss-of-function mutations in a calcium-channel α1-subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness [J].
Bech-Hansen, NT ;
Naylor, MJ ;
Maybaum, TA ;
Pearce, WG ;
Koop, B ;
Fishman, GA ;
Mets, M ;
Musarella, MA ;
Boycott, KM .
NATURE GENETICS, 1998, 19 (03) :264-267