Myxinidin2 and myxinidin3 suppress inflammatory responses through STAT3 and MAPKs to promote wound healing

被引:20
作者
Han, Hyo Mi [1 ]
Ko, Sujin [1 ]
Cheong, Min-Ju [2 ]
Bang, Jeong Kyu [3 ]
Seo, Chang Ho [4 ]
Luchian, Tudor [5 ]
Park, Yoonkyung [1 ,6 ]
机构
[1] Chosun Univ, Dept Biomed Sci, Gwangju, South Korea
[2] Chosun Univ, Dept Life Sci, Gwangju, South Korea
[3] Korea Basic Sci Inst, Div Magnet Resonance, Ochang, South Korea
[4] Kongju Natl Univ, Dept Bioinformat, Kong Ju, South Korea
[5] Alexandru I Cuza Univ, Dept Phys, Iasi, Romania
[6] Chosun Univ, Res Ctr Proteinaceous Mat, Gwangju, South Korea
基金
新加坡国家研究基金会;
关键词
myxinidin; antimicrobial peptide; STAT3; MAPKs; wound healing; STAPHYLOCOCCUS-AUREUS INFECTION; GROWTH-FACTOR RECEPTOR; PROPIONIBACTERIUM-ACNES; CYTOKINE PRODUCTION; SKIN; MICE; KERATINOCYTES; MIGRATION; PEPTIDES; HYDROGEL;
D O I
10.18632/oncotarget.20908
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Skin wounds are continuously exposed to bacteria and can easily become infected. Infected wounds require antibiotic treatment, and infections caused by drug-resistant bacteria are an important public health problem. Antimicrobial peptides have broad-spectrum antibacterial activity, induce little or no drug resistance and may be suitable for treating skin infections caused by drug-resistant bacteria. We previously reported the design and function of myxinidin and myxinidin analogues. Here we showed that myxinidin2 and myxinidin3 exhibit antimicrobial and anti-biofilm activities against antibiotic-resistant Staphylococcus aureus, Acinetobacter baumannii, and Pseudomonas aeruginosa in high salt environments and in gelatin. Moreover, these peptides facilitated infected wound healing by decreasing inflammation through suppression of IL-6, IL-8, and TNF-alpha and regulation of downstream mediators such as STAT3, p38, JNK, and EGFR. In a mouse skin wound model infected with antibiotic-resistant bacteria, myxinidin2 and myxinidin3 eliminated the infection and enhanced wound healing. We therefore propose the use of these peptides for treating infected wounds and burns.
引用
收藏
页码:87582 / 87597
页数:16
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