Squalamine: A polyvalent drug of the future?

被引：44
作者：
Brunel, JM [1 ]
Salmi, C [1 ]
Loncle, C [1 ]
Vidal, N [1 ]
Letourneux, Y [1 ]
机构：
[1] Univ Paul Cezanne, IMRN, INRA, Lab SESNAB,Fac St Jerome,UMR 1111, F-13397 Marseille, France
来源：
CURRENT CANCER DRUG TARGETS | 2005年 / 5卷 / 04期
关键词：
squalamine; aminosterol; cancer; age-related macular degeneration (AMD); appetite suppression; weight reduction;
D O I：
10.2174/1568009054064642
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The purpose of this mini-review is to summarize and highlight the different advances in our understanding of the antimicrobial and antiangiogenic activity of squalamine, a cationic steroid isolated in 1993 from the dogfish shark Squalus Acanthias. Indeed, squalamine has shown to be useful for the treatment of important diseases such as cancers (lung, ovarian, brain and others), age-related macular degeneration (AMD) and the control of body weight in man. All these results led to a question: could we consider squalamine as a polyvalent drug of the future?
引用
收藏
页码：267 / 272
页数：6
相关论文
共 45 条
  • [1] Appetite suppression and weight reduction by a centrally active aminosterol
    Ahima, RS
    Patel, HR
    Takahashi, N
    Qi, Y
    Hileman, SM
    Zasloff, MA
    [J]. DIABETES, 2002, 51 (07) : 2099 - 2104
  • [2] Squalamine, a novel cationic steroid, specifically inhibits the brush-border Na+/H+ exchanger isoform NHE3
    Akhter, S
    Nath, SK
    Tse, CM
    Williams, J
    Zasloff, M
    Donowitz, M
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1999, 276 (01): : C136 - C144
  • [3] Surveillance of antimicrobial resistance - what, how and whither?
    Bax, R
    Bywater, R
    Cornaglia, G
    Goossens, H
    Hunter, P
    Isham, V
    Jarlier, V
    Jones, R
    Phillips, I
    Sahm, D
    Senn, S
    Struelens, M
    Taylor, D
    White, A
    [J]. CLINICAL MICROBIOLOGY AND INFECTION, 2001, 7 (06) : 316 - 325
  • [4] Vascular development: Cellular and molecular regulation
    Beck, L
    DAmore, PA
    [J]. FASEB JOURNAL, 1997, 11 (05) : 365 - 373
  • [5] Bhargava P, 2001, CLIN CANCER RES, V7, P3912
  • [6] ANTIBACTERIAL PEPTIDES - KEY COMPONENTS NEEDED IN IMMUNITY
    BOMAN, HG
    [J]. CELL, 1991, 65 (02) : 205 - 207
  • [7] Recent advances in the synthesis of spermine and spermidine analogs of the shark aminosterol squalamine
    Brunel, JM
    Letourneux, Y
    [J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2003, 2003 (20) : 3897 - 3907
  • [8] Molecular mechanisms of blood vessel formation
    Bussolino, F
    Mantovani, A
    Persico, G
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (07) : 251 - 256
  • [9] Sharks: A potential source of antiangiogenic factors and tumor treatments
    Cho, JJ
    Kim, YT
    [J]. MARINE BIOTECHNOLOGY, 2002, 4 (06) : 521 - 525
  • [10] Squalamine lactate reduces choroidal neovascularization in a laser-injury model in the rat
    Ciulla, TA
    Criswell, MH
    Danis, RP
    Williams, JI
    McLane, MP
    Holroyd, KJ
    [J]. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2003, 23 (06): : 808 - 814
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