Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study

被引:32
作者
Choi, Hayoung [1 ]
Yoo, Jung Eun [2 ]
Han, Kyungdo [3 ]
Choi, Wonsuk [4 ]
Rhee, Sang Youl [5 ]
Lee, Hyun [6 ]
Shin, Dong Wook [7 ,8 ]
机构
[1] Hallym Univ, Coll Med, Kangnam Sacred Heart Hosp, Div Allergy Pulm & Crit Care Med,Dept Internal Me, Seoul, South Korea
[2] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Dept Family Med, Seoul, South Korea
[3] Soongsil Univ, Dept Stat & Actuarial Sci, Seoul, South Korea
[4] Chonnam Natl Univ, Sch Med, Dept Internal Med, Hwasun Hosp, Hwasun, South Korea
[5] Kyung Hee Univ, Sch Med, Dept Endocrinol & Metab, Seoul, South Korea
[6] Hanyang Univ, Dept Internal Med, Div Pulm Med & Allergy, Coll Med, Seoul, South Korea
[7] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Family Med, Seoul, South Korea
[8] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Dept Digital Hlth, Seoul, South Korea
基金
新加坡国家研究基金会;
关键词
diabetes mellitus; tuberculosis; body mass index; epidemiology; nutritional status; ACTIVE TUBERCULOSIS; NATIONAL-HEALTH; OBESITY; MELLITUS; GENDER; EPIDEMIOLOGY; SEX;
D O I
10.3389/fnut.2021.739766
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Although both diabetes mellitus (DM) and underweight are associated with increased risk of tuberculosis (TB), there are limited data evaluating TB risk while considering two factors simultaneously-body mass index (BMI) and DM. A retrospective cohort study was performed with 10,087,903 participants of the Korean National Health Screening Program in 2009. The cohort was followed up to the date of TB incidence, death, or until December 31, 2018. We compared the incidence and risk of TB according to BMI category and DM. During the 7.3-year follow-up duration, the incidence of TB was 0.92 per 1,000 person-years in the normal weight without DM, 2.26 in the normal weight with DM, 1.80 in the underweight without DM, and 5.35 in the underweight with DM. Compared to the normal weight without DM, the normal weight with DM, the underweight without DM, and the underweight with DM showed a 1.51-fold (95% CI, 1.46-1.57), a 2.21-fold (95% CI, 2.14-2.28), and a 3.24-fold (95% CI, 2.95-3.56) increased risk of TB, respectively. However, compared to the normal weight without DM, the severely obese without DM and those with DM showed a 0.37 (95% CI, 0.36-0.38) and a 0.42 (95% CI, 0.36-0.48)-fold decreased risk of TB, respectively. There was no significant joint effect of BMI and DM on the risk of incident TB in the overall population; a synergistic effect of underweight and DM was evident in participants <65 years of age, current smokers, and heavy drinkers. In conclusion, being underweight or DM individually increases the risk of incident TB. Based on our study results, a focused screening of incident TB in patients with DM may be beneficial.
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收藏
页数:11
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