Altered Structural-functional Coupling of Large-scale Brain Networks in Early Tourette Syndrome Children

被引:1
作者
Wen, Hongwei [1 ,2 ,3 ]
Liu, Yue [5 ]
Zhang, Jishui [6 ]
Peng, Yun [5 ]
He, Huiguang [1 ,2 ,4 ]
机构
[1] Chinese Acad Sci, Inst Automat, Res Ctr Brain Inspired Intelligence, Beijing 100190, Peoples R China
[2] Univ Chinese Acad Sci, Beijing, Peoples R China
[3] Southwest Univ, Dept Psychol, Chongqing, Peoples R China
[4] Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China
[5] Capital Med Univ, Beijing Childrens Hosp, Dept Radiol, 56 Nanlishi Rd, Beijing 100045, Peoples R China
[6] Capital Med Univ, Beijing Childrens Hosp, Dept Neurol, Beijing, Peoples R China
来源
MEDICAL IMAGING 2018: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING | 2018年 / 10578卷
基金
中国国家自然科学基金;
关键词
Tourette syndrome; Probabilistic diffusion tractography; Structural connectivity; Resting-state functional connectivity; Graph theoretical analysis; Modularity; SC-FC coupling; CONNECTIVITY;
D O I
10.1117/12.2283231
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Tourette syndrome (TS) is a childhood-onset neurobehavioral disorder and its pathophysiological mechanism remains elusive. At present, TS-related abnormalities in either structural connectivity (SC) or functional connectivity (FC) have extensively been described, and discrepancies were apparent between the SC and FC studies. However, abnormalities in the SC-FC correlation for early TS children remain poorly understood. In our study, we used probabilistic diffusion tractography and resting-state FC to construct large-scale structural and functional brain networks for 34 drug-naive TS children and 42 healthy children. Graph theoretical approaches were employed to divide the group-averaged FC networks into functional modules. The Pearson correlation between the entries of SC and FC were estimated as SC-FC coupling within whole-brain and each module. Although five common functional modules (including the sensorimotor, default-mode, fronto-parietal, temporo-occipital and subcortical modules) were identified in both groups, we found SC-FC coupling in TS exhibited increased at the whole-brain and functional modular level, especially within sensorimotor and subcortical modules. The increased SC-FC coupling may suggest that TS pathology leads to functional interactions that are more directly related to the underlying SC of the brain and may be indicative of more stringent and less dynamic brain function in TS children. Together, our study demonstrated that altered whole-brain and module-dependent SC-FC couplings may underlie abnormal brain function in TS, and highlighted the potential for using multimodal neuroimaging biomarkers for TS diagnosis as well as understanding the pathophysiologic mechanisms of TS.
引用
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页数:11
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