What Is the Significance of Soluble and Endogenous Secretory Receptor for Advanced Glycation End Products in Liver Steatosis in Obese Prepubertal Children?

被引：43
作者：
D'Adamo, Ebe [1 ,2 ]
Giannini, Cosimo [1 ,2 ]
Chiavaroli, Valentina [1 ]
de Giorgis, Tommaso [1 ]
Verrotti, Alberto [1 ]
Chiarelli, Francesco [1 ,2 ]
Mohn, Angelika [1 ,2 ]
机构：
[1] Univ G dAnnunzio, Dept Pediat, I-66100 Chieti, Italy
[2] Univ G dAnnunzio, Ctr Excellence Aging, G DAnnunzio Univ Fdn, I-66100 Chieti, Italy
来源：
ANTIOXIDANTS & REDOX SIGNALING | 2011年 / 14卷 / 06期
关键词：
FATTY LIVER; INSULIN-RESISTANCE; METABOLIC SYNDROME; RAGE;
D O I：
10.1089/ars.2010.3719
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The endogenous secretory receptor for advanced glycation end products (esRAGE) and soluble RAGE (sRAGE) have been shown in human plasma and have emerged as reliable biomarkers of several pathological conditions, including insulin resistance and liver injury. We examined esRAGE and sRAGE levels in obese prepubertal children with and without liver steatosis. esRAGE and sRAGE levels were significantly lower in obese prepubertal children affected by liver steatosis and were independently related to liver steatosis. These findings suggest that AGE-RAGE pathway plays an independent role in the development of liver injury already present in this age group. Antioxid. Redox Signal. 14, 1167-1172.
引用
收藏
页码：1167 / 1172
页数：6
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