Therapeutic effect of ketogenic diet treatment on type 2 diabetes

被引：3

作者：

Li, Fang ^{[1
]}

Shen, Yang ^{[2
]}

Chen, Qun ^{[1
]}

Li, Xingyu ^{[1
]}

Yang, Hongnan ^{[3
]}

Zhang, Canyang ^{[1
]}

Lin, Jinjun ^{[2
]}

Du, Zhicheng ^{[1
]}

Jiang, Chenyao ^{[1
]}

Yang, Chengming ^{[4
]}

Yu, Dongmei ^{[5
]}

Qin, Peiwu ^{[1
]}

机构：

[1] Tsinghua Shenzhen Int Grad Sch, Inst Biopharmaceut & Hlth Engn, Shenzhen 518101, Peoples R China

[2] Shenzhen Univ, Baoan Cent Hosp Shenzhen, Affiliated Hosp 5, Dept Endocrinol, Shenzhen 518055, Peoples R China

[3] Hangzhou Dianzi Univ, Dept Automat, Hangzhou 310016, Peoples R China

[4] Southern Univ Sci & Technol Hosp, Shenzhen 518055, Peoples R China

[5] Shandong Univ, Dept Electromech & Informat Engn, Weihai 264209, Peoples R China

来源：

JOURNAL OF FUTURE FOODS | 2022年 / 2卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Ketogenic diet; Type; 2; diabetes; Diabetic physiological parameters; MRI images; Offset of Oral Glucose Tolerance Test (SOOGTT); DEEP LEARNING-MODEL; CONVOLUTIONAL NETWORKS; SEMANTIC SEGMENTATION; POSITION STATEMENT; GLYCEMIC CONTROL; MANAGEMENT; NUTRITION;

D O I：

10.1016/j.jfutfo.2022.03.004

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Diet plays an important role in diabetes development. The effect of ketogenic diet on type 2 diabetes remains elusive. In this study, we collect diabetes related physiological parameters and abdominal MRI images to evaluate the effect of ketogenic diet after 3-months of consecutive treatment. Ketogenic diet mitigates the diabetes symptom inferring from the statistically significant reduction of key diabetic physiological parameters such as Hemoglobin A1c (HbA1c) concentration, Triglyceride (TG), Fasting blood glucose (FBG), Body Mass Index (BMI), and adipose tissue volume. Moreover, we propose a new parameter to quantify the treating effect of ketogenic diet since Slope and Offset of Oral Glucose Tolerance Test (SOOGTT) incorporate more sampling points by fitting OGTT (Oral Glucose Tolerance Test) curve. SOOGTT shows statistically significant (P < 0.001) treating effect of ketogenic diet on type 2 diabetes. We use artificial intelligence to segment adipose tissue for treatment evaluation, which shows that ketogenic diet reduces the amount of adipose tissue.

引用

页码：177 / 183

页数：7

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