The association of α-fibrinogen Thr312Ala polymorphism and venous thromboembolism in the LITE study

被引：31
作者：
Rasmussen-Torvik, Laura J.
Cushman, Mary
Tsai, Michael Y.
Zhang, Yan
Heckbert, Susan R.
Rosamond, Wayne D.
Folsom, Aaron R.
机构：
[1] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Commun Hlth, Minneapolis, MN 55454 USA
[2] Univ Vermont, Coll Med, Dept Med, Burlington, VT 05401 USA
[3] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA
[4] Univ Washington, Dept Epidemiol, Seattle, WA 98101 USA
[5] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27514 USA
来源：
THROMBOSIS RESEARCH | 2007年 / 121卷 / 01期
关键词：
deep vein thrombosis; fibrinogen; polymorphism;
D O I：
10.1016/j.thromres.2007.02.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction: The a-fibrinogen Thr312Ala variant has been shown to influence clot structure through increased factor XIII cross-linking and formation of thicker fibrin fibers. However, the effect of this common variant on risk of venous thromboembolism (VTE) is unclear. This paper reports the association between the Thr312Ala variant and VTE in the LITE study. Materials and methods: 506 cases and 1014 controls frequency matched on age, sex, race,. and study were drawn from two prospective studies and included in the analysis. Logistic regression was used to examine the association between Thr312A[a and VTE. Results: In a logistic regression model minimally adjusted for the matching variables, the Thr312Ala TA and AA genotypes were associated with a significantly higher risk of VTE than the TT genotype (TA OR and 95% confidence interval 1.27 [1.01-1.60), AA OR 1.49 [1.00-2.22]). Associations were similar in analyses of PE and DVT considered
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页码：1 / 7
页数：7
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