Aiming to solve the problem of fluid noise caused by right-angle globe valve (RGV) in pipeline systems, this paper provides optimal designs of the valve cone angle and the coordinate angle between the valve seat and cone on the basis of the numerical calculation results of RGV by adopting CFD method. Comparative analysis of the sound power level for noise and the change of cavitation number according to the change of the opening size and the inlet velocity before and after optimization demonstrates that in the same working condition, the sound power level for noise produced by the RGV reduced over 5 dB after optimization, and the cavitation number is reduced over 40% when the valve opening is less than 50%. The above-mentioned data indicate that the optimal design provided by this paper can improve the noise performance of the RGV significantly. And the research results of this paper can, to some extent, serve as guidance for the optimal design of flow passages of other kinds of valve in pipeline systems.