Total synthesis of Z-isomer of phomolide B

被引：27

作者：

Mohapatra, Debendra K. ^{[1
]}

Reddy, D. Prabhakar ^{[1
]}

Dash, Uttam ^{[1
]}

Yadav, J. S. ^{[1
]}

机构：

[1] Indian Inst Chem Technol CSIR, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 01期

关键词：

Phomolide B; Decanolides; Sharpless asymmetric epoxidation; Yamaguchi esterification; Ring-closing metathesis; RING-CLOSING METATHESIS; 1ST TOTAL-SYNTHESIS; STEREOSELECTIVE TOTAL-SYNTHESIS; LACTONE HERBARUMIN-III; OLEFIN METATHESIS; STAGONOSPORA-CIRSII; CHOLESTEROL-BIOSYNTHESIS; POTENTIAL MYCOHERBICIDE; ABSOLUTE-CONFIGURATION; 10-MEMBERED MACROLIDES;

D O I：

10.1016/j.tetlet.2010.11.003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have achieved the synthesis of Z-isomer of phomolide B during our investigation toward the effect of protecting group on the outcome of ring-closing metathesis reaction. The other key reactions involved are cis-selective partial hydrogenation. Sharpless asymmetric epoxidation, Yamaguchi esteritication, and following 12 longest linear sequence with 18.5% overall yield starting from a known intermediate 20. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：151 / 154

页数：4

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