Small airway function in Finnish COVID-19 survivors

被引：16

作者：

Lindahl, Anna ^{[1
,2
]}

Reijula, Jere ^{[3
]}

Malmberg, Leo Pekka ^{[4
,5
]}

Aro, Miia ^{[2
]}

Vasankari, Tuula ^{[2
,6
]}

Makela, Mika Juhani ^{[4
,5
]}

机构：

[1] Univ Helsinki, Fac Med, Helsinki, Finland

[2] Finnish Lung Hlth Assoc, Sibeliuksenkatu 11 A1, Helsinki 00250, Finland

[3] Helsinki Univ Hosp, Dept Pulmonol, Helsinki, Finland

[4] Univ Helsinki, Skin & Allergy Hosp, Helsinki, Finland

[5] Helsinki Univ Hosp, Helsinki, Finland

[6] Univ Turku, Dept Pulm Dis & Clin Allergol, Fac Med, Turku, Finland

来源：

RESPIRATORY RESEARCH | 2021年 / 22卷 / 01期

关键词：

COVID-19; Small airways; Airway inflammation; Viral infection; Nitric oxide; Impulse oscillometry; REFERENCE VALUES; SPIROMETRY;

D O I：

10.1186/s12931-021-01830-9

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Follow-up studies of COVID-19 patients have found lung function impairment up to six months after initial infection, but small airway function has not previously been studied. Patients (n = 20) hospitalised for a severe SARS-CoV-2 infection underwent spirometry, impulse oscillometry, and multiple measurements of alveolar nitric oxide three to six months after acute infection. None of the patients had small airway obstruction, nor increased nitric oxide concentration in the alveolar level. None of the patients had a reduced FEV1/FVC or significant bronchodilator responses in IOS or spirometry. In conclusion, we found no evidence of inflammation or dysfunction in the small airways.

引用

页数：5

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