High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways

被引:6
作者
Saber, Zahra Mehrazad [1 ,2 ]
Takeuchi, Yoshinori [1 ,2 ]
Sawada, Yoshikazu [1 ]
Aita, Yuichi [1 ,2 ]
Ho, Man Hei [1 ,2 ]
Karkoutly, Samia [1 ,2 ]
Tao, Duhan [1 ,2 ]
Katabami, Kyoka [1 ,2 ]
Ye, Chen [1 ,2 ]
Murayama, Yuki [1 ,2 ]
Shikama, Akito [1 ,2 ]
Masuda, Yukari [1 ]
Izumida, Yoshihiko [1 ]
Miyamoto, Takafumi [2 ]
Matsuzaka, Takashi [2 ]
Sugasawa, Takehito [2 ]
Takekoshi, Kazuhiro [2 ]
Kawakami, Yasushi [2 ]
Shimano, Hitoshi [2 ]
Yahagi, Naoya [1 ,2 ]
机构
[1] Univ Tsukuba, Fac Med, Nutrigen Res Grp, Tsukuba, Ibaraki, Japan
[2] Univ Tsukuba, Dept Internal Med Endocrinol & Metab, Fac Med, Tsukuba, Ibaraki, Japan
关键词
Amino acids; Transcription factor; High protein diet; In vivo imaging; Nutrigenomics; UREA-CYCLE ENZYMES; AMINO-ACID-METABOLISM; WEIGHT-LOSS; RAT-LIVER; MECHANISMS; GLUCONEOGENESIS; METAANALYSIS; ADAPTATION; INDUCTION; NUTRIENT;
D O I
10.1016/j.bbrc.2021.10.027
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
High protein diet (HPD) is an affordable and positive approach in prevention and treatment of many diseases. It is believed that transcriptional regulation is responsible for adaptation after HPD feeding and Kruppel-like factor 15 (KLF15), a zinc finger transcription factor that has been proved to perform transcriptional regulation over amino acid, lipid and glucose metabolism, is known to be involved at least in part in this HPD response. To gain more insight into molecular mechanisms by which HPD controls expressions of genes involved in amino acid metabolism in the liver, we performed RNA-seq analysis of mice fed HPD for a short period (3 days). Compared to a low protein diet, HPD feeding significantly increased hepatic expressions of enzymes involved in the breakdown of all the 20 amino acids. Moreover, using KLF15 knockout mice and in vivo Ad-luc analytical system, we were able to identify Cth (cystathionine gamma-lyase) as a new target gene of KLF15 transcription as well as Ast (aspartate aminotransferase) as an example of KLF15-independent gene despite its remarkable responsiveness to HPD. These findings provide us with a clue to elucidate the entire transcriptional regulatory mechanisms of amino acid metabolic pathways. (c) 2021 Elsevier Inc. All rights reserved.
引用
收藏
页码:35 / 42
页数:8
相关论文
共 57 条
  • [1] Obesity and the metabolic syndrome: role of different dietary macronutrient distribution patterns and specific nutritional components on weight loss and maintenance
    Abete, Itziar
    Astrup, Arne
    Alfredo Martinez, J.
    Thorsdottir, Inga
    Zulet, Maria A.
    [J]. NUTRITION REVIEWS, 2010, 68 (04) : 214 - 231
  • [2] ASSOCIATIONS AMONG FOOD AND PROTEIN INTAKE SERINE DEHYDRATASE AND PLASMA AMINO ACIDS
    ANDERSON, HL
    BENEVENG.NJ
    HARPER, AE
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1968, 214 (05): : 1008 - +
  • [3] Protein: A nutrient in focus
    Arentson-Lantz, Emily
    Clairmont, Stephanie
    Paddon-Jones, Douglas
    Tremblay, Angelo
    Elango, Rajavel
    [J]. APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, 2015, 40 (08) : 755 - 761
  • [4] Higher Branched-chain Amino Acids and Lower Serine Exist in the Plasma of Nondiabetic Mice: A Comparison Between High- and Low-protein Diet Conditions
    Arimura, Emi
    Ushikai, Miharu
    Horiuchi, Masahisa
    [J]. IN VIVO, 2021, 35 (03): : 1554 - 1560
  • [5] Effects of a whey protein supplementation on intrahepatocellular lipids in obese female patients
    Bortolotti, Murielle
    Maiolo, Elena
    Corazza, Mattia
    Van Dijke, Eveline
    Schneiter, Philippe
    Boss, Andreas
    Carrel, Guillaume
    Giusti, Vittorio
    Le, Kim-Anne
    Chong, Daniel Guae Quo
    Buehler, Tania
    Kreis, Roland
    Boesch, Chris
    Tappy, Luc
    [J]. CLINICAL NUTRITION, 2011, 30 (04) : 494 - 498
  • [6] Skeletal muscle protein metabolism in the elderly: Interventions to counteract the 'anabolic resistance' of ageing
    Breen, Leigh
    Phillips, Stuart M.
    [J]. NUTRITION & METABOLISM, 2011, 8
  • [7] High dietary protein decreases fat deposition induced by high-fat and high-sucrose diet in rats
    Chaumontet, Catherine
    Even, Patrick C.
    Schwarz, Jessica
    Simonin-Foucault, Angelique
    Piedcoq, Julien
    Fromentin, Gilles
    Azzout-Marniche, Dalila
    Tome, Daniel
    [J]. BRITISH JOURNAL OF NUTRITION, 2015, 114 (08) : 1132 - 1142
  • [8] SAR1B senses leucine levels to regulate mTORC1 signalling
    Chen, Jie
    Ou, Yuhui
    Luo, Rong
    Wang, Jie
    Wang, Dong
    Guan, Jialiang
    Li, Yi
    Xia, Peixue
    Chen, Peng R.
    Liu, Ying
    [J]. NATURE, 2021, 596 (7871) : 281 - +
  • [9] Systematic review and meta-analysis of the effect of protein and amino acid supplements in older adults with acute or chronic conditions
    Cheng, Heilok
    Kong, Jielan
    Underwood, Catherine
    Petocz, Peter
    Hirani, Vasant
    Dawson, Beryl
    O'Leary, Fiona
    [J]. BRITISH JOURNAL OF NUTRITION, 2018, 119 (05) : 527 - 542
  • [10] Sarcopenia: European consensus on definition and diagnosis
    Cruz-Jentoft, Alfonso J.
    Baeyens, Jean Pierre
    Bauer, Juergen M.
    Boirie, Yves
    Cederholm, Tommy
    Landi, Francesco
    Martin, Finbarr C.
    Michel, Jean-Pierre
    Rolland, Yves
    Schneider, Stephane M.
    Topinkova, Eva
    Vandewoude, Maurits
    Zamboni, Mauro
    [J]. AGE AND AGEING, 2010, 39 (04) : 412 - 423