Resorcinosides A and B, Glycosylated Alkylresorcinols from a Marine-Derived Strain of the Fungus Penicillium janthinellum

被引：16

作者：

Choi, Byeoung-Kyu ^{[1
,2
]}

Thi Hoai Trinh Phan ^{[3
,4
]}

Hwang, Sunghoon ^{[5
]}

Oh, Dong-Chan ^{[5
]}

Kang, Jong Soon ^{[6
]}

Lee, Hwa-Sun ^{[2
]}

Thi Duy Ngoc Ngo ^{[3
]}

Thi Thanh Van Tran ^{[3
,4
]}

Shin, Hee Jae ^{[1
,2
]}

机构：

[1] UST, Dept Marine Biotechnol, 217 Gajungro, Daejeon 34113, South Korea

[2] KIOST, Marine Nat Prod Chem Lab, 385 Haeyang Ro, Busan 49111, South Korea

[3] Vietnam Acad Sci & Technol, Nha Trang Inst Technol Res & Applicat, 02 Hung Vuong, Nha Trang 650000, Vietnam

[4] Grad Univ Sci & Technol, Vietnam Acad Sci & Technol, 18 Hoang Quoc Viet, Hanoi 100000, Vietnam

[5] Seoul Natl Univ, Nat Prod Res Inst, Coll Pharm, Seoul 08826, South Korea

[6] Korea Res Inst Biosci & Biotechnol, Lab Anim Resource Ctr, 30 Yeongudanjiro, Cheongju 28116, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 11期

关键词：

GLUCOSIDES; LEAVES; RYE;

D O I：

10.1021/acs.jnatprod.9b00776

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new glycosylated alkylresorcinols, resorcinosides A (1) and B (2), were isolated from a strain of the fungus Penicillium janthinellum derived from a marine sediment sample collected from Cu Lao Cham Island, Vietnam. The structures of 1 and 2 were established by interpretation of 1D and 2D NMR and high-resolution ESIMS data, and their absolute configurations were confirmed by the coupling constant of the anomeric proton, acid hydrolysis, subsequent HPLC analysis, Mosher's method, and quantum-mechanics-based computational analysis of NMR chemical shifts. The structure elucidation indicated that 1 and 2 are new alkylresorcinols with D-glucose, and 2 has an a-pyrone moiety attached to the aromatic ring. Compound 1 exhibited cytotoxic activity against the NUGC-3 cancer cell line with a GI(50) value of 9.3 mu M.

引用

页码：3186 / 3190

页数：5

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