Methylenetetrahydrofolate reductase gene polymorphisms in patients with schizophrenia

被引：50

作者：

Sazci, A ^{[1
]}

Ergül, E

Güzelhan, Y

Kaya, G

Kara, I

机构：

[1] Univ Kocaeli, Fac Med, Dept Med Biol & Genet, TR-41900 Kocaeli, Turkey

[2] Univ Istanbul, Dept Neurosci, Inst Med Res, TR-34280 Istanbul, Turkey

来源：

MOLECULAR BRAIN RESEARCH | 2003年 / 117卷 / 01期

关键词：

schizophrenia; MTHFR; polymorphism; association; genotyping;

D O I：

10.1016/S0169-328X(03)00327-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To investigate the role of methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, we analyzed the genotypes of MTHFR677 and MTHFR1298 of 130 schizophrenic patients and 226 controls, using a polymerase chain reaction restriction fragment length polymorphism method. The MTHFR T677 allele was significantly distributed (chi(2) = 7.900; P = 0.019), between schizophrenic cases and healthy controls. The T677T genotype was overrepresented in the schizophrenic patients (OR = 2.504; 95% CI = 1.276-4.915; 2 chi(2) = 7.477; P = 0.006). The T677T/A1298A, and C677T/C1298C compound genotypes were greater in the schizophrenic patients, (OR = 3.157; 95% CI = 1.522-6.545; chi(2) = 10.336; P = 0.001 and OR = 1.744; 95% CI = 0.108-28.121; chi(2) = 0.158; P = 0.691, respectively). The MTHFR T677 allele and T677T and T677T/A1298A genotypes are genetic risk factors for schizophrenia. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：104 / 107

页数：4

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