Surface Enhanced Raman Spectroscopy for Malaria Diagnosis and Intradermal Measurements

被引：2

作者：

Liu, Quan ^{[1
]}

Yuen, Clement ^{[1
]}

Chen, Keren ^{[1
]}

Ju, Jian ^{[1
]}

Xiong, Aoli ^{[2
]}

Preiser, Peter ^{[2
]}

机构：

[1] Nanyang Technol Univ, Sch Chem & Biomed Engn, Singapore 637457, Singapore

[2] Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore

来源：

PLASMONICS IN BIOLOGY AND MEDICINE XV | 2018年 / 10509卷

关键词：

Raman; surface enhanced Raman scattering (SERS); silver; malaria; hemozoin; intradermal measurements; microneedle; agarose; BETA-HEMATIN; IN-VIVO; HEMOZOIN FORMATION; PIGMENT; SCATTERING; NANOPARTICLES; MECHANISM;

D O I：

10.1117/12.2294539

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The biomarkers of many diseases such as malaria can be found in intradermal measurements. We will present two surface enhanced Raman spectroscopy (SERS) based methods for the detection of malaria biomarkers in blood, which are comparable to or outperform the standard clinical method. To eliminate the need of drawing blood, we will also report a stainless-steel microneedle based probe for direct intradermal SERS measurements. Moreover, we developed a deformable agarose needle to reduce the risk of sharp injury and cross contamination due to needle reuse. Tests in skin phantoms for glucose measurements demonstrated accuracy comparable to those traditional methods requiring blood drawing.

引用

页数：14

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