An outbreak of the desert sub-type of zoonotic visceral leishmaniasis in Jiashi, Xinjiang Uygur Autonomous Region, People's Republic of China

被引:40
作者
Wang, Jun-Yun [1 ,6 ]
Gao, Chun-Hua [1 ,6 ]
Yang, Yue-Tao [1 ,6 ]
Chen, Hai-Tang [1 ,6 ]
Zhu, Xue-Hua [1 ,6 ]
Lv, Shan [1 ,6 ]
Chen, Sheng-Bang [2 ]
Tong, Su-Xiang [3 ]
Steinmann, Peter [1 ,4 ,5 ,6 ]
Ziegelbauer, Kathrin [4 ,5 ]
Zhou, Xiao-Nong [1 ,6 ]
机构
[1] Chinese Ctr Dis Control & Prevent, Natl Inst Parasit Dis, Shanghai 200025, Peoples R China
[2] Gansu Prov Ctr Dis Control & Prevent, Lanzhou 730020, Peoples R China
[3] Ctr Dis Control & Prevent Xinjiang Uygur Autonomo, Urumqi 830002, Peoples R China
[4] Swiss Trop & Publ Hlth Inst, CH-4002 Basel, Switzerland
[5] Univ Basel, Basel, Switzerland
[6] WHO Collaborating Ctr Malaria Schistosomiasis & F, Shanghai 200025, Peoples R China
关键词
Visceral leishmaniasis; Outbreak; Leishmania donovani; Leishmania infantum; China; KALA-AZAR OUTBREAK; CUTANEOUS LEISHMANIASIS; DIAGNOSIS; IDENTIFICATION; KINETOPLAST; DISEASES; HEALTH;
D O I
10.1016/j.parint.2010.04.002
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Few outbreaks of the desert sub-type of zoonotic visceral leishmaniasis (VL) have been described worldwide. In 2008, the incidence rate of VL in Jiashi County, Xinjiang Uygur Autonomous Region in the western part of the People's Republic of China, increased more than twenty-folds compared to the average annual incidence rate. The majority of the cases (96.6%) occurred among <2 year-old infants. For the first time in the desert area of Xinjiang, the parasites were isolated from bone marrow aspirates, using the NNN medium culture approach. The genetic analysis of the ITS-1 nucleotide sequence indicated that three isolates from eastern Jiashi County were genetically closely related and belonged to the Leishmania infantum group. However, they differed from an isolate from Kashi city which was classified as a member of the Leishmania donovani group. (c) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:331 / 337
页数:7
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