A review of biotransformation and pharmacology of ginsenoside compound K

被引：218
作者：
Yang, Xi-Ding [1 ,2 ]
Yang, Yong-Yu [2 ]
Ouyang, Dong-Sheng [3 ]
Yang, Guo-Ping [1 ]
机构：
[1] Cent South Univ, Xiangya Hosp 3, Ctr Clin Pharmacol, Changsha 410013, Hunan, Peoples R China
[2] Cent South Univ, Sch Pharmaceut Sci, Changsha 410013, Hunan, Peoples R China
[3] Cent South Univ, Inst Clin Pharmacol, Changsha 410078, Hunan, Peoples R China
来源：
FITOTERAPIA | 2015年 / 100卷
关键词：
Ginsenoside compound K; Ginseng; Biotransformation; Pharmacological activities; PROTOPANAXADIOL-TYPE GINSENOSIDES; INTESTINAL BACTERIAL METABOLITE; THERMOSTABLE BETA-GLYCOSIDASE; ADJUVANT-INDUCED ARTHRITIS; ACTIVATED PROTEIN-KINASE; PANAX-GINSENG; SAPONIN METABOLITE; IN-VITRO; ANTIINFLAMMATORY MECHANISM; HEPATOCELLULAR-CARCINOMA;
D O I：
10.1016/j.fitote.2014.11.019
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
As an intestinal bacterial metabolite of ginseng protopanaxadiol saponins, ginsenoside compound K (20-O-beta-o-glucopyranosyl-20(S)-protopanaxadiol, CK) is a major deglycosylated metabolite form of ginsenosides which is absorbed into the systemic circulation. And it has demonstrated such diverse intriguing biological properties as anticarcinogenic, anti-inflammation, antiallergic, anti-diabetic, anti-angiogenesis, anti-aging, neuroprotective and hepatoprotective effects. The present review shall summarize recent studies on various biotransformation and pharmacological activities of CIC. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：208 / 220
页数：13
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