Serum cytokine concentrations, flavonol intake and colorectal adenoma recurrence in the Polyp Prevention Trial

被引：22
作者：
Bobe, G. [1 ]
Murphy, G. [2 ]
Albert, P. S. [3 ]
Sansbury, L. B. [4 ]
Lanza, E. [1 ]
Schatzkin, A. [5 ]
Colburn, N. H. [1 ]
Cross, A. J. [5 ]
机构：
[1] NCI, Lab Canc Prevent, Ctr Canc Res, NIH,Dept Hlth & Human Serv, Frederick, MD 21702 USA
[2] NCI, Infect & Immunoepidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA
[3] NICHHD, Biostat & Bioinformat Branch, NIH, DHHS, Bethesda, MD 20892 USA
[4] NCI, Epidemiol & Genet Res Program, Div Canc Control & Populat Sci, NIH,DHHS, Bethesda, MD 20892 USA
[5] NCI, Nutr Epidemiol Branch, DCEG, NIH,DHHS, Bethesda, MD 20892 USA
来源：
BRITISH JOURNAL OF CANCER | 2010年 / 103卷 / 09期
关键词：
cancer prevention; colorectal adenoma; colorectal cancer; cytokines; flavonols; QUERCETIN-INDUCED APOPTOSIS; COLONY-STIMULATING FACTOR; NF-KAPPA-B; DIETARY FLAVONOIDS; GENE-EXPRESSION; ANTIINFLAMMATORY ACTIVITY; PROGNOSTIC-SIGNIFICANCE; GRANULOCYTE-MACROPHAGE; INFLAMMATORY CYTOKINES; INHIBITORY-ACTIVITY;
D O I：
10.1038/sj.bjc.6605915
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACKGROUND: Serum cytokine concentrations may reflect inflammatory processes occurring during the development of colorectal neoplasms. Flavonols, bioactive compounds found in plant-based foods and beverages, may inhibit colorectal neoplasms partly by attenuating inflammation. METHODS: Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to investigate the association between serum concentrations of interleukin (IL) 1 beta, 2, 8, 10, 12p70, granulocyte macrophage colony stimulating factor, interferon-gamma, and tumour necrosis factor-alpha, measured over time, flavonol intake, estimated from a flavonol database used in conjunction with a food frequency questionnaire, and adenoma recurrence in 872 participants from the intervention arm of the Polyp Prevention Trial. RESULTS: Decreased IL-2 concentration during the trial increased the risk of any adenoma recurrence (4th vs 1st quartile, OR = 1.68, 95% CI = 1.13-2.49), whereas decreased IL-1 beta or IL-10 reduced the risk of advanced adenoma recurrence (OR = 0.37, 95% CI = 0.15-0.94; OR = 0.39, 95% CI = 0.15-0.98, respectively). Individuals with flavonol intake above the median (29.7 mg per day) and decreased cytokine concentrations had the lowest risk of advanced adenoma recurrence. CONCLUSION: Overall, no consistent associations were observed between serum cytokine profile and colorectal adenoma recurrence; however, decreased cytokine concentrations during high flavonol consumption may indicate prevention of colorectal neoplasms. British Journal of Cancer (2010) 103, 1453-1461. doi: 10.1038/sj.bjc.6605915 www.bjcancer.com Published online 5 October 2010 (C) 2010 Cancer Research UK
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页码：1453 / 1461
页数：9
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