When to Screen Children with Down Syndrome for Celiac Disease?

被引：10

作者：

Pavlovic, Momcilo ^{[1
]}

Radlovic, Nedeljko ^{[2
]}

Lekovic, Zoran ^{[2
]}

Stojsic, Zorica ^{[3
]}

Puleva, Katja ^{[1
]}

Berenji, Karolina ^{[4
]}

机构：

[1] Gen Hosp Subotica, Dept Pediat, Subotica 24000, Serbia

[2] Univ Children Hosp, Dept Gastroenterol, Belgrade 11000, Serbia

[3] Inst Pathol, Belgrade 11000, Serbia

[4] Inst Publ Hlth, Subotica 24000, Serbia

来源：

JOURNAL OF TROPICAL PEDIATRICS | 2010年 / 56卷 / 06期

关键词：

celiac disease; Down syndrome; tissue transglutaminase; PREVALENCE;

D O I：

10.1093/tropej/fmq026

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The coexistence of Down syndrome (DS) and celiac disease (CD) has been reported in many studies. In our study, we examined 82 children with DS aged 8 months to 8.6 years for the existence of CD using serological markers immunoglobulin A (IgA) and immunoglobulin G (IgG) transglutaminase antibodies, followed by follow-up determination of total IgA levels. In four children who were positive for one of the above-mentioned antibodies, enteric biopsy has been performed that showed absence of CD. Our findings raise doubt about the need for obligatory serological screening of children with DS aged <8 years.

引用

页码：443 / 445

页数：3

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