Hormetic and anti-inflammatory properties of oxidized phospholipids

被引:36
作者
Mauerhofer, Christina [1 ]
Philippova, Maria [2 ]
Oskolkova, Olga V. [1 ]
Bochkov, Valery N. [1 ]
机构
[1] Graz Univ, Inst Pharmaceut Sci, Humboldtstr 46-3, A-8010 Graz, Austria
[2] Univ Basel Hosp, Dept Biomed, Hebelstr 20, CH-4031 Basel, Switzerland
基金
奥地利科学基金会;
关键词
Hormesis; Inflammation; Lung barrier; Immuno-modulation; TLR; PPAR; ACTIVATED RECEPTOR-GAMMA; BARRIER-PROTECTIVE RESPONSE; LOW-DENSITY-LIPOPROTEIN; ACUTE LUNG INJURY; ENDOTHELIAL-CELLS; HEME OXYGENASE-1; IN-VIVO; OXIDATION-PRODUCTS; STRUCTURAL IDENTIFICATION; FACTOR ACETYLHYDROLASE;
D O I
10.1016/j.mam.2016.02.003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Oxidized phospholipids are generally recognized as deleterious factors involved in disease pathogenesis. This review summarizes the data suggesting that under certain biological conditions the opposite is correct, namely that OxPLs can also induce protective effects. Examples that are discussed in the review include upregulation of antioxidant genes, inhibition of inflammatory signaling pathways through Nrf2-dependent and -independent mechanisms, antagonism of Toll-like receptors, immuno-modulating and immunosuppressive action of OxPLs in adaptive immunity and autoimmune disease, activation of PPARs known for their anti-inflammatory action, as well as protective action against lung edema in acute lung inflammation. The data support the notion that oxidation of phospholipids provides a negative feedback preventing damage to host tissues due to uncontrolled inflammation and oxidative stress. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:78 / 90
页数:13
相关论文
共 99 条
[1]   Nrf2 in health and disease: current and future clinical implications [J].
Al-Sawaf, Othman ;
Clarner, Tim ;
Fragoulis, Athanassios ;
Kan, Yuet Wai ;
Pufe, Thomas ;
Streetz, Konrad ;
Wruck, Christoph Jan .
CLINICAL SCIENCE, 2015, 129 (12) :989-999
[2]   Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation [J].
Aldrovandi, Maceler ;
Hammond, Victoria J. ;
Podmore, Helen ;
Hornshaw, Martin ;
Clark, Stephen R. ;
Marnett, Lawrence J. ;
Slatter, David A. ;
Murphy, Robert C. ;
Collins, Peter W. ;
O'Donnell, Valerie B. .
JOURNAL OF LIPID RESEARCH, 2013, 54 (11) :3085-3097
[3]   Oxidized PLs and Vascular Inflammation [J].
Aldrovandi, Maceler ;
O'Donnell, Valerie B. .
CURRENT ATHEROSCLEROSIS REPORTS, 2013, 15 (05)
[4]   Transient and prolonged increase in endothelial permeability induced by histamine and thrombin -: Role of protein kinases, calcium, and RhoA [J].
Amerongen, GPV ;
Draijer, R ;
Vermeer, MA ;
van Hinsbergh, VWM .
CIRCULATION RESEARCH, 1998, 83 (11) :1115-1123
[5]   Rap1 promotes cell spreading by localizing Rac guanine nucleoticle exchange factors [J].
Arthur, WT ;
Quilliam, LA ;
Cooper, JA .
JOURNAL OF CELL BIOLOGY, 2004, 167 (01) :111-122
[6]   Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac [J].
Birukov, KG ;
Bochkov, VN ;
Birukova, AA ;
Kawkitinarong, K ;
Rios, A ;
Leitner, A ;
Verin, AD ;
Bokoch, GM ;
Leitinger, N ;
Garcia, JGN .
CIRCULATION RESEARCH, 2004, 95 (09) :892-901
[7]   Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction [J].
Birukova, AA ;
Smurova, K ;
Birukov, KG ;
Kaibuchi, K ;
Garcia, JGN ;
Verin, AD .
MICROVASCULAR RESEARCH, 2004, 67 (01) :64-77
[8]   ALK5 and Smad4 are involved in TGF-β1-induced pulmonary endothelial permeability [J].
Birukova, AA ;
Adyshev, D ;
Gorshkov, B ;
Birukov, KG ;
Verin, AD .
FEBS LETTERS, 2005, 579 (18) :4031-4037
[9]   Prostaglandins PGE2 and PGI2 promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation [J].
Birukova, Anna A. ;
Zagranichnaya, Tatiana ;
Fu, Panfeng ;
Alekseeva, Elena ;
Chen, Weiguo ;
Jacobson, Jeffrey R. ;
Birukov, Konstantin G. .
EXPERIMENTAL CELL RESEARCH, 2007, 313 (11) :2504-2520
[10]   Polar head groups are important for barrier-protective effects of oxidized phospholipids on pulmonary endothelium [J].
Birukova, Anna A. ;
Fu, Panfeng ;
Chatchavalvanich, Santipongse ;
Burdette, Dylan ;
Oskolkova, Olga ;
Bochkov, Valery N. ;
Birukov, Konstantin G. .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2007, 292 (04) :L924-L935