Synthesis and structure revision of symplocin A

被引：0

作者：

Shao, Lu-Ping ^{[1
]}

Si, Chang-Mei ^{[1
]}

Mao, Zhuo-Ya ^{[1
]}

Zhou, Wen ^{[1
]}

Molinski, Tadeusz F. ^{[2
,3
]}

Wei, Bang-Guo ^{[1
]}

Lin, Guo-Qiang ^{[1
]}

机构：

[1] Fudan Univ, Sch Pharm, Dept Nat Prod Chem, 826 Zhangheng Rd, Shanghai 201203, Peoples R China

[2] Univ Calif San Diego, Dept Chem & Biochem, 9500 Gilman Dr, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, 9500 Gilman Dr, La Jolla, CA 92093 USA

来源：

ORGANIC CHEMISTRY FRONTIERS | 2017年 / 4卷 / 06期

基金：

美国国家卫生研究院; 中国博士后科学基金; 中国国家自然科学基金;

关键词：

MARINE CYCLIC DEPSIPEPTIDE; ASYMMETRIC-SYNTHESIS; ANTIMALARIAL ACTIVITY; PEPTIDE-SYNTHESIS; DOLASTATIN; 10; CYANOBACTERIUM; ANALOG; INHIBITORS; ACIDS; 1-HYDROXY-7-AZABENZOTRIAZOLE;

D O I：

10.1039/c7qo00052a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Symplocin A, a linear peptide possessing N-terminal N, N-dimethylisoleucine, statine, and valic acid residues, has been synthesized for the first time employing our previously established 'one-pot intramolecular tandem protocol'. Moreover, the stereochemistry of natural symplocin A was unambiguously revised through the confirmation by 1D NMR, 2D NMR, and HPLC comparisons with an authentic natural product.

引用

页码：995 / 1004

页数：10

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