An overview of MCT1 and MCT4 in GBM: small molecule transporters with large implications

被引：2

作者：

Park, Simon J. ^{[1
]}

Smith, Chase P. ^{[1
]}

Wilbur, Ryan R. ^{[1
]}

Cain, Charles P. ^{[1
]}

Kallu, Sankeerth R. ^{[1
]}

Valasapalli, Srijan ^{[1
]}

Sahoo, Arpit ^{[1
]}

Guda, Maheedhara R. ^{[1
]}

Tsung, Andrew J. ^{[1
,2
,4
]}

Velpula, Kiran K. ^{[1
,2
,3
]}

机构：

[1] Univ Illinois, Coll Med Peoria, Dept Canc Biol & Pharmacol, One Illini Dr, Peoria, IL 61656 USA

[2] Univ Illinois, Coll Med Peoria, Dept Neurosurg, One Illini Dr, Peoria, IL 61656 USA

[3] Univ Illinois, Coll Med Peoria, Dept Pediat, One Illini Dr, Peoria, IL 61656 USA

[4] Illinois Neurol Inst, Peoria, IL USA

来源：

AMERICAN JOURNAL OF CANCER RESEARCH | 2018年 / 8卷 / 10期

关键词：

Monocarboxylate transporter; MCT1; MCT4; glioblastoma; cancer; LACTATE/H+ SYMPORTERS MCT1; TISSUE-SPECIFIC POLARITY; LACTIC-ACID EFFLUX; MONOCARBOXYLATE TRANSPORTERS; GLIOBLASTOMA CELLS; CHAPERONE CD147; SKELETAL-MUSCLE; STEM-CELLS; KEY PLAYER; EXPRESSION;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Monocarboxylate transporters (MCTs) represent a diverse group of transmembrane proteins encoded by the SLC16 gene family found ubiquitously across mammalian species. Two members of this family, MCT1 and MCT4, have been linked to key roles in the metabolic activity of tissues through the proton-coupled transport of monocarboxylates, most notably L-lactate, ketone bodies, and pyruvate. This review aims to provide an overview of MCT1 and MCT4, followed by the implications of their expression in a multitude of cancers and in glioblastoma (GBM) specifically. Further, the possible mechanisms underlying these effects will be discussed. Given the relationships between MCT1 and MCT4 and cancer, they offer a unique opportunity for novel treatment strategies. We aim to explore current therapies focused on MCT1 and MCT4 and propose future studies to better understand their role in GBM to optimize future treatment regimens.

引用

页码：1967 / 1976

页数：10

共 67 条

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