Antimicrobial activity of hyperbranched polymers: Synthesis, characterization, and activity assay study

被引：10

作者：

Kanai, Tapan ^{[1
]}

Thirumoolan, D. ^{[2
]}

Mohanram, R. ^{[3
]}

Vetrivel, K. ^{[2
]}

Basha, K. Anver ^{[2
]}

机构：

[1] Naval Mat Res Lab, Div Polymer, Additional Ambernath 421506, Ambernath, India

[2] C Abdul Hakeem Coll, PG & Res Dept Chem, Melvisharam, India

[3] Naval Mat Res Lab, Dept Marine Biotechnol, Ambernath 421506, India

来源：

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 2015年 / 30卷 / 02期

关键词：

Hyperbranched polymers; nuclear magnetic resonance; Michael addition; antibacterial activity assay; minimum inhibitory concentration; POLYESTERS; DENDRIMERS; ACID; HYDROLYSIS; COMPLEXES; HEATS;

D O I：

10.1177/0883911514565936

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Poly(cyanurateamine) and poly(triacrylatetrimine) hyperbranched polymers were synthesized for the first time by adopting Michael addition reaction. These polymers were obtained by reacting diethylenetriamine (A(2)) with 2,4,6-triallylcyanurate (B-3) and trimethylolpropane triacrylate (B-3), respectively, at room temperature. The polymers were characterized by spectroscopic techniques such as Fourier transform infrared, 1H-, and 13C-nuclear magnetic resonance spectroscopy. The antimicrobial activity of hyperbranched polymers was studied against Staphylococcus aureus ATCC 25923, Escherichia coli, Bacillus firmus, Bacillus subtilis MTCC 2423, Serratia marcescens, Pseudomonas aeruginosa, Micrococcus sp., and Acinetobacter beijerinckii. Both poly(cyanurateamine) and poly(triacrylatetrimine) show good antibacterial activity against gram-positive bacteria compared to gram-negative bacteria. Interestingly, poly(triacrylatetrimine) is better resistant to promising antibiotics and antiseptics bacteria, Pseudomonas aeruginosa and Serratia marcescens in comparison with poly(cyanurateamine).

引用

页码：145 / 156

页数：12

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