Expression of the Insulin-like Growth Factor-1 Receptor in Odontogenic Myxoma

被引：0

作者：

Friedrich, Reinhard E. ^{[1
]}

Hagel, Christian ^{[2
]}

Zustin, Jozef ^{[3
]}

机构：

[1] Univ Hamburg, Eppendorf Univ Hosp, Dept Oral & Craniomaxillofacial Surg, D-20246 Hamburg, Germany

[2] Univ Hamburg, Eppendorf Univ Hosp, Inst Neuropathol, D-20246 Hamburg, Germany

[3] Royal Natl Orthopaed Hosp NHS Trust Histopathol, Bone Tumours & Metab Bone Dis, London, England

来源：

ANTICANCER RESEARCH | 2016年 / 36卷 / 06期

关键词：

Odontogenic myxoma; immunohistochemistry; IGF-1R; odontogenic tumour; rare tumours; STEM-CELLS EXPRESS; FACTOR-SYSTEM; IMMUNOHISTOCHEMICAL LOCALIZATION; NESTIN EXPRESSION; TUMORS; RAT; PODOPLANIN; COMPONENTS; TISSUE; TEETH;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Odontogenic myxoma (OM) is a rare mesenchymal tumour arising in the jaws. The origin and pathogenesis of OM is poorly understood. The aim of this study was to characterize OM by immunolocalization of certain antigens in the tumour that are relevant for cellular differentiation, migration and maintenance. Materials and Methods: Five OMs were immunohistochemically investigated for expression of nestin, CD133, podoplanin, and insulin-like growth factor 1 receptor (IGF-1R). Results: OM failed to react with antibodies applied in this study, with the exception of IGF-1R in tumour cells. Discussion: OM is a poorly characterized benign, invasive tumour of the jaws. The absence of stem cell marker in OM does not exclude possible temporary expression of these antigens during certain phases of tumour development. The identification of IGF-1R in OM is shared with numerous tumours and indicates the ability of these tumour cells to respond to growth factors.

引用

页码：3103 / 3107

页数：5

共 45 条

[1] Nestin expression in embryonic and adult human teeth under normal and pathological conditions
About, I
Laurent-Maquin, D
Lendahl, U
Mitsiadis, TA
[J]. AMERICAN JOURNAL OF PATHOLOGY, 2000, 157 (01) : 287 - 295
[2] FIBROMYXOMA OF THE FEMORAL-NECK
ADLER, CP
[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1981, 101 (02) : 183 - 189
[3] Insulin-like growth factors in embryonic and fetal growth and skeletal development (Review)
Agrogiannis, Georgios D.
Sifakis, Stavros
Patsouris, Efstratios S.
Konstantinidou, Anastasia E.
[J]. MOLECULAR MEDICINE REPORTS, 2014, 10 (02) : 579 - 584
[4] Extragnathic Sino-Orbital Myxoma: An Extremely Rare Tumor at an Even Rarer Site
Ali, Mohammad Javed
Saha, Debarati
Vemuganti, Geeta K.
Naik, Milind N.
[J]. OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY, 2014, 30 (06) : E157 - E159
[5] IGF-I: A mitogen also involved in differentiation processes in mammalian cells
Benito, M
Valverde, AM
Lorenzo, M
[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1996, 28 (05) : 499 - 510
[6] Substrate competitive inhibitors of IGF-1 receptor kinase
Blum, G
Gazit, A
Levitzki, A
[J]. BIOCHEMISTRY, 2000, 39 (51) : 15705 - 15712
[7] Boson WL, 1998, ANTICANCER RES, V18, P4415
[8] BreitenederGeleff S, 1997, AM J PATHOL, V151, P1141
[9] Expression of insulin-like growth factor-1 receptor in human pulp tissue
Caviedes-Bucheli, J
Muñoz, HR
Rodríguez, CE
Lorenzana, TC
Moreno, GC
Lombana, N
[J]. JOURNAL OF ENDODONTICS, 2004, 30 (11) : 767 - 769
[10] Expression of insulin-like growth factor-1 and proliferating cell nuclear antigen in human pulp cells of teeth with complete and incomplete root development
Caviedes-Bucheli, J.
Canales-Sanchez, P.
Castrillon-Sarria, N.
Jovel-Garcia, J.
Alvarez-Vasquez, J.
Rivero, C.
Azuero-Holguin, M. M.
Diaz, E.
Munoz, H. R.
[J]. INTERNATIONAL ENDODONTIC JOURNAL, 2009, 42 (08) : 686 - 693

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