Cloning of the novel gene TM6SF1 reveals conservation of clusters of paralogous genes be tween human chromosomes 15q24→q26 and 19p13.3→p12

被引：30

作者：

Carim-Todd, L ^{[1
]}

Escarceller, M ^{[1
]}

Estivill, X ^{[1
]}

Sumoy, L ^{[1
]}

机构：

[1] Hosp Duran & Reynals, Inst Recerca Oncol, Med & Mol Genet Ctr, E-08907 Barcelona, Spain

来源：

CYTOGENETICS AND CELL GENETICS | 2000年 / 90卷 / 3-4期

关键词：

D O I：

10.1159/000056784

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

As the result of the EUROIMAGE Consortium sequencing project, we have isolated and characterized a novel gene on chromosome 15, TM6SF1. It encodes a 370 amino acid product with enhanced expression in spleen, testis and peripheral blood leukocytes. We have identified another gene, paralogous to TM6SF1 on chromosome 19p12, TM6SF2, with an overall similarity of 68 % and 52 % identity at the protein level. This conservation has led us to uncover a series of eleven genes in 19p13.3-->p12 with close homology to genes in 15q24-->q26. The percentage of sequence similarity between each paralogous pair of genes at the protein level ranges between 43 and 89 %. A partial conservation of synteny with mouse chromosomes 7, 8 and 9 is also observed. The corresponding orthologous genes in mouse of human TM6SF1 and TM6SF2 show a high degree of amino acid sequence conservation. Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：255 / 260

页数：6

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