Aryl Radical Selectivity in Biphasic Systems

被引：9
作者：
Altmann, Lisa-Marie
Fuerst, Michael C. D.
Gans, Eva I.
Zantop, Viviane
Pratsch, Gerald
Heinrich, Markus R.
机构：
[1] Department of Chemistry and Pharmacy, Pharmaceutical Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nikolaus-Fiebiger-Strasse 10, Erlangen
来源：
ORGANIC LETTERS | 2020年 / 22卷 / 02期
关键词：
TYROSINE RESIDUES; ARYLATION; ACTIVATION; CHEMISTRY; PHENOLS;
D O I：
10.1021/acs.orglett.9b04237
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Aryl radicals generated in the aqueous phase of biphasic mixtures have-regardless of a comparably low polarity- a strong preference to react with aromatic substrates in the aqueous phase and not to undergo phase-transfer into a lipophilic phase, independent from the presence of a surfactant. These results represent an important prerequisite toward future studies in biological systems, which typically consist of various compartments of either hydrophilic or lipophilic character.
引用
收藏
页码：479 / 482
页数：4
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