Adsorption of proteins on a lipid bilayer

被引：7
|
作者：
Zhdanov, Vladimir P. [1 ,2 ]
Kasemo, Bengt [2 ]
机构：
[1] Russian Acad Sci, Boreskov Inst Catalysis, Novosibirsk 630090, Russia
[2] Chalmers, Dept Appl Phys, S-41296 Gothenburg, Sweden
来源：
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS | 2010年 / 39卷 / 11期
关键词：
Proteins; Lipids; Adsorption energy; Electrostatic interactions; Poisson-Boltzmann equation; ATOMIC-FORCE MICROSCOPY; MONTE-CARLO SIMULATIONS; MARCKS-RELATED PROTEIN; CHARGED MACROMOLECULES; SOLID-SURFACES; QCM-D; MEMBRANES; BINDING; AFM;
D O I：
10.1007/s00249-010-0604-0
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
In our analysis of protein adsorption on a lipid bilayer, the protein surface is considered to contain one or a few charged spots, and the bilayer contains a significant amount of lipids with oppositely charged head groups. After adsorption, a folded protein is assumed to change its shape slightly due to the electrostatic attraction, so that one of the spots forms a flat contact with the oppositely charged lipid heads of the lipid bilayer. With realistic parameters, this model predicts that the contribution of electrostatic interactions to the protein adsorption energy per charged amino acid-lipid pair is 16-25 kJ/mol. Thus, a few (four or five) pairs is sufficient for irreversible adsorption.
引用
收藏
页码：1477 / 1482
页数：6
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