New drug treatments show neuroprotective effects in Alzheimer's and Parkinson's diseases

被引：21

作者：

Hoelscher, Christian ^{[1
]}

机构：

[1] Univ Lancaster, Fac Hlth & Med, Neurosci Res Grp, Lancaster LA1 4YQ, England

来源：

NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 21期

关键词：

neurodegeneration; neurotrophic factors; neuroprotection; growth factor; memory; amyloid; AMYLOID-BETA OLIGOMERS; NERVE GROWTH-FACTOR; NEURAL STEM-CELLS; NEUROTROPHIC FACTOR; INTRANASAL INSULIN; GENE-THERAPY; MOUSE MODEL; BRAIN; RESISTANCE; IMPAIRMENT;

D O I：

10.4103/1673-5374.145342

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Type 2 diabetes is a risk factor for Alzheimer's disease and Parkinson's disease. Insulin signaling in the brains of people with Alzheimer's disease or Parkinson's disease is impaired. Preclinical studies of growth factors showed impressive neuroprotective effects. In animal models of Alzheimer's disease and Parkinson's disease, insulin, glia-derived neurotrophic factor, or analogues of the incretin glucagori-like peptide-1 prevented neurodegenerative processes and improved neuronal and synaptic functionality in Alzheimer's disease and Parkinson's disease. On the basis of these promising findings, several clinical trials are ongoing with the first encouraging clinical results published. This gives hope for developing effective treatments for Alzheimer's disease and Parkinson's disease that are currently unavailable.

引用

页码：1870 / 1873

页数：4

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