Long-lived C-elegans daf-2 mutants are resistant to bacterial pathogens

被引:448
|
作者
Garsin, DA
Villanueva, JM
Begun, J
Kim, DH
Sifri, CD
Calderwood, SB
Ruvkun, G
Ausubel, FM [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA
[4] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
关键词
D O I
10.1126/science.1080147
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:1921 / 1921
页数:1
相关论文
共 50 条
  • [41] Apparent uncoupling of energy production and consumption in long-lived Clk mutants of Caenorhabditis elegans
    Braeckman, BP
    Houthoofd, K
    De Vreese, A
    Vanfleteren, JR
    CURRENT BIOLOGY, 1999, 9 (09) : 493 - 496
  • [42] Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans
    Miyadera, H
    Amino, H
    Hiraishi, A
    Taka, H
    Murayama, K
    Miyoshi, H
    Sakamoto, K
    Ishii, N
    Hekimi, S
    Kita, K
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (11) : 7713 - 7716
  • [43] Daf-2 Signaling Modifies Mutant SOD1 Toxicity in C. elegans
    Boccitto, Marco
    Lamitina, Todd
    Kalb, Robert G.
    PLOS ONE, 2012, 7 (03):
  • [44] Adapting the innate immune system to develop long-lived vaccines to bacterial pathogens
    Super, Michael
    Doherty, Edward
    Cartwright, Mark
    Stafford, Alexander
    Ali, Onnar
    White, Des
    Graveline, Amanda
    Urena, Frank
    MacDonald, Chloe
    Dinis, Alexandre
    Duffy, Shannon
    Duckless, Benjamin
    Seiler, Benjamin
    Lngber, Donald
    Mooney, David
    JOURNAL OF IMMUNOLOGY, 2017, 198 (01):
  • [45] Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2
    Ayyadevara, S
    Dandapat, A
    Singh, SP
    Benes, H
    Zimniak, L
    Reis, RJS
    Zimniak, P
    AGING CELL, 2005, 4 (06) : 299 - 307
  • [46] Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C-elegans insulin gene family
    Pierce, SB
    Costa, M
    Wisotzkey, R
    Devadhar, S
    Homburger, SA
    Buchman, AR
    Ferguson, KC
    Heller, J
    Platt, DM
    Pasquinelli, AA
    Liu, LX
    Doberstein, SK
    Ruvkun, G
    GENES & DEVELOPMENT, 2001, 15 (06) : 672 - 686
  • [47] Is life span extension in single gene long-lived Caenorhabditis elegans mutants due to hypometabolism?
    Van Voorhies, WA
    EXPERIMENTAL GERONTOLOGY, 2003, 38 (06) : 615 - 618
  • [48] Activated SKN-1 alters the aging trajectories of long-lived Caenorhabditis elegans mutants
    Turner, Chris D.
    Curran, Sean P.
    GENETICS, 2025,
  • [49] Fluoxetine-resistant mutants in C-elegans define a novel family of transmembrane proteins
    Choy, RKM
    Thomas, JH
    MOLECULAR CELL, 1999, 4 (02) : 143 - 152
  • [50] Daf-16 mediated repression of cytosolic ribosomal protein genes facilitates a hypoxia sensitive to hypoxia resistant transformation in long-lived germline mutants
    Hemphill, Cassidy
    Pylarinou-Sinclair, Evye
    Itani, Omar
    Scott, Barbara
    Crowder, C. Michael
    Van Gilst, Marc Ryan
    PLOS GENETICS, 2022, 18 (05):