Long-lived C-elegans daf-2 mutants are resistant to bacterial pathogens

被引：448
|
作者：
Garsin, DA
Villanueva, JM
Begun, J
Kim, DH
Sifri, CD
Calderwood, SB
Ruvkun, G
Ausubel, FM [1 ]
机构：
[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA
[4] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
来源：
SCIENCE | 2003年 / 300卷 / 5627期
关键词：
D O I：
10.1126/science.1080147
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：1921 / 1921
页数：1
相关论文
共 50 条
  • [31] SAGE surveys C-elegans carbohydrate metabolism:: evidence for an anaerobic shift in the long-lived dauer larva
    Holt, SJ
    Riddle, DL
    MECHANISMS OF AGEING AND DEVELOPMENT, 2003, 124 (07) : 779 - 800
  • [32] Characterization of PUD-1 and PUD-2, Two Proteins Up-Regulated in a Long-Lived daf-2 Mutant
    Ding, Yue-He
    Du, Yun-Guang
    Luo, Shukun
    Li, Yu-Xin
    Li, Tie-Mei
    Yoshina, Sawako
    Wang, Xing
    Klage, Karsten
    Mitani, Shohei
    Ye, Keqiong
    Dong, Meng-Qiu
    PLOS ONE, 2013, 8 (06):
  • [33] DAF-16 and Δ9 Desaturase Genes Promote Cold Tolerance in Long-Lived Caenorhabditis elegans age-1 Mutants
    Savory, Fiona R.
    Sait, Steven M.
    Hope, Ian A.
    PLOS ONE, 2011, 6 (09):
  • [34] H3K9me1/2 methylation limits the lifespan of daf-2 mutants in C. elegans
    Huang, Meng
    Hong, Minjie
    Hou, Xinhao
    Zhu, Chengming
    Chen, Di
    Chen, Xiangyang
    Guang, Shouhong
    Feng, Xuezhu
    ELIFE, 2022, 11
  • [35] ACTIVATED SKN-1 ALTERS THE LONGEVITY TRAJECTORY OF LONG-LIVED C. ELEGANS MUTANTS
    Turner, Chris
    Curran, Sean
    INNOVATION IN AGING, 2024, 8 : 1132 - 1132
  • [36] Long-lived mitochondrial (Mit) mutants of Caenorhabditis elegans utilize a novel metabolism
    Butler, Jeffrey A.
    Ventura, Natascia
    Johnson, Thomas E.
    Rea, Shane L.
    FASEB JOURNAL, 2010, 24 (12): : 4977 - 4988
  • [37] Isolation of long-lived mutants in Caenorhabditis elegans using selection for resistance to juglone
    De Castro, E
    De Castro, SH
    Johnson, TE
    FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 (02) : 139 - 145
  • [38] C-elegans produce reactive oxygen species in response to bacterial pathogens
    Garsin, D
    FREE RADICAL BIOLOGY AND MEDICINE, 2005, 39 : S176 - S176
  • [39] Activation of DAF-16/FOX0 by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans
    Senchuk, Megan M.
    Dues, Dylan J.
    Scheer, Claire E.
    Johnson, Benjamin K.
    Madaj, Zachary B.
    Bowman, Megan J.
    Winn, Mary E.
    Van Reamsdonk, Jeremy M.
    PLOS GENETICS, 2018, 14 (03):
  • [40] Decline in oxygen consumption correlates with lifespan in long-lived and short-lived mutants of Caenorhabditis elegans
    Shoyama, Tetsuji
    Shimizu, Yuka
    Suda, Hitoshi
    EXPERIMENTAL GERONTOLOGY, 2009, 44 (12) : 784 - 791
12345