Long-lived C-elegans daf-2 mutants are resistant to bacterial pathogens

被引：448
|
作者：
Garsin, DA
Villanueva, JM
Begun, J
Kim, DH
Sifri, CD
Calderwood, SB
Ruvkun, G
Ausubel, FM [1 ]
机构：
[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA
[4] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
来源：
SCIENCE | 2003年 / 300卷 / 5627期
关键词：
D O I：
10.1126/science.1080147
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：1921 / 1921
页数：1
相关论文
共 50 条
  • [1] LONG-LIVED MUTANTS OF C-ELEGANS
    PERRIN, T
    EGILMEZ, N
    REIS, RJS
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1992, 203 : 88 - CHED
  • [2] Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression
    Halaschek-Wiener, J
    Khattra, JS
    McKay, S
    Pouzyrev, A
    Stott, JM
    Yang, GS
    Holt, RA
    Jones, SJM
    Marra, MA
    Brooks-Wilson, AR
    Riddle, DL
    GENOME RESEARCH, 2005, 15 (05) : 603 - 615
  • [3] Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans
    Barsyte, D
    Lovejoy, DA
    Lithgow, GJ
    FASEB JOURNAL, 2001, 15 (03): : 627 - 634
  • [4] Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans
    McElwee, JJ
    Schuster, E
    Blanc, E
    Thornton, J
    Gems, D
    MECHANISMS OF AGEING AND DEVELOPMENT, 2006, 127 (05) : 458 - 472
  • [5] Bacterial resistance of daf-2 mutants
    Bolm, M
    Chhatwal, GS
    Jansen, WTM
    SCIENCE, 2004, 303 (5666) : 1976 - 1976
  • [6] Shared transcriptional signature in Caenorhabditis elegans dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance
    McElwee, JJ
    Schuster, E
    Blanc, E
    Thomas, JH
    Gems, D
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (43) : 44533 - 44543
  • [7] Proteomic Analyses of Caenorhabditis elegans Dauer Larvae and Long-Lived daf-2 Mutants Implicates a Shared Detoxification System in Longevity Assurance
    Jones, Laura M.
    Staffa, Katharina
    Perally, Samirah
    LaCourse, E. James
    Brophy, Peter M.
    Hamilton, Jo V.
    JOURNAL OF PROTEOME RESEARCH, 2010, 9 (06) : 2871 - 2881
  • [8] Long-lived C-elegans mitochondrial mutants as a model for human mitochondrial-associated diseases
    Ventura, Natascia
    Rea, Shane L.
    Testi, Roberto
    EXPERIMENTAL GERONTOLOGY, 2006, 41 (10) : 974 - 991
  • [9] Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans (vol 127, pg 458, 2006)
    McElwee, Joshua J.
    Schuster, Eugene
    Blanc, Eric
    Thornton, Janet
    Gems, David
    MECHANISMS OF AGEING AND DEVELOPMENT, 2006, 127 (12) : 922 - 936
  • [10] Cell nonautonomy of C-elegans daf-2 function in the regulation of diapause and life span
    Apfeld, J
    Kenyon, C
    CELL, 1998, 95 (02) : 199 - 210
12345