Long-lived C-elegans daf-2 mutants are resistant to bacterial pathogens

被引:453
作者
Garsin, DA
Villanueva, JM
Begun, J
Kim, DH
Sifri, CD
Calderwood, SB
Ruvkun, G
Ausubel, FM [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA
[4] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
关键词
D O I
10.1126/science.1080147
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
[No abstract available]
引用
收藏
页码:1921 / 1921
页数:1
相关论文
共 7 条
[1]   Caenorhabditis elegans as a host for the study of host-pathogen interactions [J].
Aballay, A ;
Ausubel, FM .
CURRENT OPINION IN MICROBIOLOGY, 2002, 5 (01) :97-101
[2]   The genetics of aging [J].
Finch, CE ;
Ruvkun, G .
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2001, 2 :435-462
[3]  
Garigan D, 2002, GENETICS, V161, P1101
[4]   A simple model host for identifying Gram-positive virulence factors [J].
Garsin, DA ;
Sifri, CD ;
Mylonakis, E ;
Qin, X ;
Singh, KV ;
Murray, BE ;
Calderwood, SB ;
Ausubel, FM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (19) :10892-10897
[5]   A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity [J].
Kim, DH ;
Feinbaum, R ;
Alloing, G ;
Emerson, FE ;
Garsin, DA ;
Inoue, H ;
Tanaka-Hino, M ;
Hisamoto, N ;
Matsumoto, K ;
Tan, MW ;
Ausubel, FM .
SCIENCE, 2002, 297 (5581) :623-626
[6]   Inducible antibacterial defense system in C-elegans [J].
Mallo, GV ;
Kurz, CL ;
Couillault, C ;
Pujol, N ;
Granjeaud, S ;
Kohara, Y ;
Ewbank, JJ .
CURRENT BIOLOGY, 2002, 12 (14) :1209-1214
[7]   Regulation of C-elegans life-span by insulinlike signaling in the nervous system [J].
Wolkow, CA ;
Kimura, KD ;
Lee, MS ;
Ruvkun, G .
SCIENCE, 2000, 290 (5489) :147-150