The tethered aminohydroxylation (TA) reaction

被引：53

作者：

Donohoe, TJ ^{[1
]}

Johnson, PD ^{[1
]}

Pye, RJ ^{[1
]}

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 12期

关键词：

D O I：

10.1039/b305189g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Since Sharpless' discovery of the asymmetric aminohydroxylation ( AA) reaction, a major challenge for chemists has been to find ways of controlling the regio- and stereochemical outcome of this important reaction. Detailed herein is a review of our novel approach towards gaining reliable and predictable regio- and stereocontrol through the use of a tethered carbamate to promote an intramolecular AA reaction, along with a description of the mechanism proposed for this new methodology.

引用

页码：2025 / 2028

页数：4

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2-D

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