Meiotic nondisjunction of chromosomes 1, 17, 18, X, and Y in men more than 80 years of age

被引：20
作者：
Guttenbach, M
Köhn, FM
Engel, W
Schmid, M
机构：
[1] Univ Wurzburg, Inst Humangenet, Biozentrum, D-97074 Wurzburg, Germany
[2] Klin & Poliklin Dermatol & Allergol, D-80802 Munich, Germany
[3] Univ Gottingen, Inst Humangenet, D-37073 Gottingen, Germany
来源：
BIOLOGY OF REPRODUCTION | 2000年 / 63卷 / 06期
关键词：
aging; meiosis; sperm;
D O I：
10.1095/biolreprod63.6.1727
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In order to evaluate a possible paternal age effect, testicular sperm cells from three men aged 81, 82, and 83 yr were analyzed by two-color- and three-color-fluorescence in situ hybridization for disomy rates of chromosomes 1, 17, 18, X, and Y as well as for diploidy frequencies. A minimum of 1500 sperm cells per donor and probe was evaluated due to the low number of spermatozoa in the preparations. Diploidy and disomy frequencies were in the same range as found in men aged <30 yr, a slight increase only being noticed for XY nuclei.
引用
收藏
页码：1727 / 1729
页数：3
相关论文
共 19 条
[1]   ON THE PARENTAL ORIGIN OF DENOVO MUTATION IN MAN [J].
CHANDLEY, AC .
JOURNAL OF MEDICAL GENETICS, 1991, 28 (04) :217-223
[2]   CLONING OF HUMAN SATELLITE-III DNA - DIFFERENT COMPONENTS ARE ON DIFFERENT CHROMOSOMES [J].
COOKE, HJ ;
HINDLEY, J .
NUCLEIC ACIDS RESEARCH, 1979, 6 (10) :3177-3197
[3]   Detection of chromosomes and estimation of aneuploidy in human spermatozoa using fluorescence in-situ hybridization [J].
Downie, SE ;
Flaherty, SP ;
Matthews, CD .
MOLECULAR HUMAN REPRODUCTION, 1997, 3 (07) :585-598
[4]   The incidence, origin, and etiology of aneuploidy [J].
Griffin, DK .
INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 167, 1996, 167 :263-296
[5]   NONDISJUNCTION IN HUMAN SPERM - EVIDENCE FOR AN EFFECT OF INCREASING PATERNAL AGE [J].
GRIFFIN, DK ;
ABRUZZO, MA ;
MILLIE, EA ;
SHEEAN, LA ;
FEINGOLD, E ;
SHERMAN, SL ;
HASSOLD, TJ .
HUMAN MOLECULAR GENETICS, 1995, 4 (12) :2227-2232
[6]   Segregation of sex chromosomes into sperm nuclei in a man with 47,XXY Klinefelter's karyotype: A FISH analysis [J].
Guttenbach, M ;
Michelmann, HW ;
Hinney, B ;
Engel, W ;
Schmid, M .
HUMAN GENETICS, 1997, 99 (04) :474-477
[7]   Analysis of structural and numerical chromosome abnormalities in sperm of normal men and carriers of constitutional chromosome aberrations. A review [J].
Guttenbach, M ;
Engel, W ;
Schmid, M .
HUMAN GENETICS, 1997, 100 (01) :1-21
[8]   CHROMOSOME-ABNORMALITIES IN HUMAN REPRODUCTIVE WASTAGE [J].
HASSOLD, TJ .
TRENDS IN GENETICS, 1986, 2 (04) :105-110
[9]  
HOOK EB, 1982, HUM GENET, V62, P167
[10]  
HOOK EB, 1990, HUM GENET, V85, P387
12