An environmentally benign and efficient synthesis of substituted benzothiazole-2-thiols, benzoxazole-2-thiols, and benzimidazoline-2-thiones in water

被引：74

作者：

Liu, Xing ^{[1
]}

Liu, Min ^{[1
]}

Xu, Wan ^{[1
]}

Zeng, Meng-Tian ^{[1
]}

Zhu, Hui ^{[1
]}

Chang, Cai-Zhu ^{[1
]}

Dong, Zhi-Bing ^{[1
]}

机构：

[1] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430205, Hubei, Peoples R China

来源：

GREEN CHEMISTRY | 2017年 / 19卷 / 23期

基金：

中国国家自然科学基金;

关键词：

CATALYZED TANDEM REACTION; CARBON-DISULFIDE; DERIVATIVES; INHIBITION; CYCLOOXYGENASE; ACTIVATION; THIOUREAS; ANALOGS; FACILE; SULFUR;

D O I：

10.1039/c7gc02311a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and practical method for the one-step synthesis of benzothiazole-2-thiols, benzoxazole-2thiols and benzimidazoline-2-thiones by cyclization of 2-aminothiophenols, 2-aminophenols, and 1,2-phenylenediamines with tetramethylthiuram disulfide (TMTD) in water was described. The features of this method include metal/ligand-free, excellent yield, short reaction time and broad substrate scope. The method provides a facile and convenient preparation of some potentially biologically active compounds.

引用

页码：5591 / 5598

页数：8

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