Is hydroxychloroquine beneficial for COVID-19 patients?

被引：62
作者：
Li, Xing [1 ]
Wang, Ying [2 ]
Agostinis, Patrizia [3 ]
Rabson, Arnold [4 ]
Melino, Gerry [5 ]
Carafoli, Ernesto [6 ]
Shi, Yufang [2 ,7 ]
Sun, Erwei [1 ,8 ]
机构：
[1] Southern Med Univ, Affiliated Hosp 3, Dept Rheumatol & Immunol, 183 Zhongshan Ave West, Guangzhou 510630, Guangdong, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China
[3] Katholieke Univ Leuven, VIB KU Leuven Ctr Canc Biol, Leuven, Belgium
[4] Rutgers State Univ, Robert Wood Johnson Med Sch, Child Hlth Inst New Jersey, New Brunswick, NJ USA
[5] Univ Roma Tor Vergata, TOR, I-00133 Rome, Italy
[6] Univ Padua, Venetian Inst Mol Med, Rome, Italy
[7] Soochow Univ, State Key Lab Radiat Med & Protect, Affiliated Hosp 1, Inst Translat Med,Med Coll, Suzhou, Peoples R China
[8] Southern Med Univ, Shunde Hosp, Dept Rheumatol & Immunol, Peoples Hosp Shunde 1, Foshan 528000, Guangdong, Peoples R China
来源：
CELL DEATH & DISEASE | 2020年 / 11卷 / 07期
关键词：
ANTIMALARIAL-DRUGS; CHLOROQUINE; INFECTION; INHIBIT; CELLS;
D O I：
10.1038/s41419-020-2721-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in December 2019. As similar cases rapidly emerged around the world(1-3), the World Health Organization (WHO) declared a public health emergency of international concern on January 30, 2020 and pronounced the rapidly spreading coronavirus outbreak as a pandemic on March 11, 2020(4). The virus has reached almost all countries of the globe. As of June 3, 2020, the accumulated confirmed cases reached 6,479,405 with more than 383,013 deaths worldwide. The urgent and emergency care of COVID-19 patients calls for effective drugs, in addition to the beneficial effects of remdesivir(5), to control the disease and halt the pandemic.
引用
收藏
页数：6
相关论文
共 68 条
  • [1] Chloroquine analogues in drug discovery: new directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases
    Al-Bari, Md. Abdul Alim
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2015, 70 (06) : 1608 - 1621
  • [2] Cutting Edge: Antimalarial Drugs Inhibit IFN-β Production through Blockade of Cyclic GMP-AMP Synthase-DNA Interaction
    An, Jie
    Woodward, Joshua J.
    Sasaki, Tomikazu
    Minie, Mark
    Elkon, Keith B.
    [J]. JOURNAL OF IMMUNOLOGY, 2015, 194 (09) : 4089 - 4093
  • [3] Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis (Expression of Concern of 10.1016/S0140-6736(20)31180-6, 2020)
    不详
    [J]. LANCET, 2020, 395 (10240) : E102 - E102
  • [4] Lysosomes as dynamic regulators of cell and organismal homeostasis
    Ballabio, Andrea
    Bonifacino, Juan S.
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2020, 21 (02) : 101 - 118
  • [5] Remdesivir for the Treatment of Covid-19-Final Report
    Beigel, John H.
    Tomashek, Kay M.
    Dodd, Lori E.
    Mehta, Aneesh K.
    Zingman, Barry S.
    Kalil, Andre C.
    Hohmann, Elizabeth
    Chu, Helen Y.
    Luetkemeyer, Annie
    Kline, Susan
    de Castilla, Diego Lopez
    Finberg, Robert W.
    Dierberg, Kerry
    Tapson, Victor
    Hsieh, Lanny
    Patterson, Thomas F.
    Paredes, Roger
    Sweeney, Daniel A.
    Short, William R.
    Touloumi, Giota
    Lye, David Chien
    Ohmagari, Norio
    Oh, Myoung-don
    Ruiz-Palacios, Guillermo M.
    Benfield, Thomas
    Faetkenheuer, Gerd
    Kortepeter, Mark G.
    Atmar, Robert L.
    Creech, C. Buddy
    Lundgren, Jens
    Babiker, Abdel G.
    Pett, Sarah
    Neaton, James D.
    Burgess, Timothy H.
    Bonnett, Tyler
    Green, Michelle
    Makowski, Mat
    Osinusi, Anu
    Nayak, Seema
    Lane, H. Clifford
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (19) : 1813 - 1826
  • [6] Hydroxychloroquine: From Malaria to Autoimmunity
    Ben-Zvi, Ilan
    Kivity, Shaye
    Langevitz, Pnina
    Shoenfeld, Yehuda
    [J]. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2012, 42 (02) : 145 - 153
  • [7] Cardiac Complications Attributed to Chloroquine and Hydroxychloroquine: A Systematic Review of the Literature
    Chatre, Clotilde
    Roubille, Francois
    Vernhet, Helene
    Jorgensen, Christian
    Pers, Yves-Marie
    [J]. DRUG SAFETY, 2018, 41 (10) : 919 - 931
  • [8] COVID-19 infection: the China and Italy perspectives
    Chen, Jun
    Lu, Hongzhou
    Melino, Gerry
    Boccia, Stefania
    Piacentini, Mauro
    Ricciardi, Walter
    Wang, Ying
    Shi, Yufang
    Zhu, Tongyu
    [J]. CELL DEATH & DISEASE, 2020, 11 (06)
  • [9] Dysregulated autophagy contributes to caspase-dependent neuronal apoptosis
    Chung, Yuhyun
    Lee, Juhyung
    Jung, Shinae
    Lee, Yangsin
    Cho, Jin Won
    Oh, Young J.
    [J]. CELL DEATH & DISEASE, 2018, 9
  • [10] Heart conduction disorders related to antimalarials toxicity: an analysis of electrocardiograms in 85 patients treated with hydroxychloroquine for connective tissue diseases
    Costedoat-Chalumeau, N.
    Hulot, J.-S.
    Amoura, Z.
    Leroux, G.
    Lechat, P.
    Funck-Brentano, C.
    Piette, J.-C.
    [J]. RHEUMATOLOGY, 2007, 46 (05) : 808 - 810
1234567