Purification of a novel substance from skeletal muscles with motoneuron survival activity: It is non-peptidergic

被引：1

作者：

Ui-Tei, K

Takamiya, M

Nagano, M

Suzuki, H

Suzuki, A

Kataoka, H

Miyata, Y

机构：

[1] Nippon Med Sch, Dept Pharmacol, Bunkyo Ku, Tokyo 1138602, Japan

[2] Univ Tokyo, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, Japan

来源：

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES | 1999年 / 75卷 / 03期

基金：

日本学术振兴会;

关键词：

survival activity; non-peptide; spinal motoneuron; skeletal muscle; chick embryo;

D O I：

10.2183/pjab.75.54

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We purified a novel substance with survival activity for spinal motoneurons from skeletal muscles of chick embryos. The purification procedure using various column chromatographies was described. The purified substance showed a maximum UV absorbance at 258 nm, which suggests that it is non-peptidergic in nature. This is the first report to show that a non-peptidergic substance exhibits the survival activity on spinal motoneurons. A possible candidate for the substance was discussed.

引用

页码：54 / 58

页数：5

共 22 条

[1] A UNIFYING HYPOTHESIS FOR THE CAUSE OF AMYOTROPHIC LATERAL SCLEROSIS, PARKINSONISM, AND ALZHEIMER-DISEASE [J].