CuCl-catalyzed stereoselective conjugate addition of Grignard reagents to 2,3-allenoates

被引：4

作者：

He, Jian ^{[1
]}

Lu, Zhan ^{[1
]}

Chai, Guobi ^{[1
]}

Fu, Chunling ^{[1
]}

Ma, Shengming ^{[1
]}

机构：

[1] Zhejiang Univ, Lab Mol Recognit & Synth, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China

来源：

TETRAHEDRON | 2012年 / 68卷 / 12期

基金：

中国国家自然科学基金;

关键词：

2,3-Allenoates; Grignard reagents; Copper-catalysis; Conjugate addition; CARBOCUPRATION;

D O I：

10.1016/j.tet.2012.01.027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

CuCl was found to be an efficient catalyst for the conjugate addition of 2,3-allenoates with Grignard reagents to synthesize poly-substituted beta,gamma-unsaturated alkenoates with high stereoselectivity in good to excellent yields. Primary, secondary, and tertiary alkyl, vinyl or phenyl Grignard reagents may all be used. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2719 / 2724

页数：6

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