A prospective study of stress and alcohol craving in heavy drinkers

被引:20
作者
Tartter, Molly A. [1 ]
Ray, Lara A. [1 ]
机构
[1] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA
关键词
Alcohol craving; Stress induction; Alcohol use disorders; OPRM1; CRH-BP; CORTICOTROPIN-RELEASING-FACTOR; PITUITARY-ADRENAL AXIS; MU-OPIOID RECEPTOR; NEUROPEPTIDE-Y; CUE REACTIVITY; HPA-AXIS; DRUG CUE; SENSITIVITY; OPRM1; POLYMORPHISM;
D O I
10.1016/j.pbb.2012.03.007
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Recent work has examined the relationship between stress and relapse to alcohol use in clinical populations. Few prospective studies, however, have examined stress as a precipitant of alcohol problems. The present study is a longitudinal examination of the role of stress reactivity and alcohol craving in the etiology of alcohol problems in a sample of 41 (mean age = 20.8), heavy-drinking, young adults. Participants completed a guided imagery exposure to stressful life events, followed by exposure to a neutral imagery control. Following the exposure, participants completed an alcohol cue exposure paradigm. Measures of negative mood (Profile of Mood States (POMS) depression/dejection scale), tension (POMS tension/anxiety scale) and alcohol craving (measured by the Alcohol Urge Questionnaire (AUQ)) were used as indicators of reactivity to stress and to alcohol cues. Polymorphisms of the corticotropin-releasing hormone binding protein (CRH-BP) gene and of the mu-opioid receptor (OPRM1) gene were examined as moderators of this relationship. Results revealed that stress-induced negative mood predicted negative consequences of drinking (scores on the Drinker's Inventory of Consequences (DrInC-2R)), whereas stress and cue-induced alcohol craving did not predict alcohol use or problems. Additionally, the CRH-BP genotype was found to moderate the relationship between stress-induced negative affect and the negative consequences of drinking. The current study supports and extends laboratory research describing phenotypes of stress-induced alcohol craving. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:625 / 631
页数:7
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