Highly biocompatible phenylboronic acid-functionalized graphitic carbon nitride quantum dots for the selective glucose sensor

被引：66

作者：

Ngo, Yen-Linh Thi ^{[1
]}

Choi, Won Mook ^{[1
]}

Chung, Jin Suk ^{[1
]}

Hur, Seung Hyun ^{[1
]}

机构：

[1] Univ Ulsan, Sch Chem Engn, Daehak Ro 93, Ulsan 44610, South Korea

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2019年 / 282卷

基金：

新加坡国家研究基金会;

关键词：

Glucose sensor; Graphitic carbon nitride; Quantum dot; Phenyl boronic acid; Fluorescence; Bio-imaging; REDUCED GRAPHENE OXIDE; BORONIC ACID; FLUORESCENT-PROBE; SENSITIVE DETECTION; AQUEOUS-SOLUTION; NANOSHEETS; FACILE; IONS;

D O I：

10.1016/j.snb.2018.11.031

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Highly biocompatible phenylboronic acid-functionalized graphitic carbon nitride quantum dots (g-CNQDs/PBA) were prepared by a simple hydrothermal process and used as a glucose sensing fluorescence material. Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction, and transmission electron microscopy were used to characterize chemical and physical structures of g-CNQDs/PBA. The quantum yield (QY) of g-CNQDs/PBA was as high as 67% when measured using quinine sulfate as a standard, which is the highest QY value ever reported for fluorescent g-CNQDs. The g-CNQDs/PBA exhibited two wide linear regions in the range of 25 nM - 1 mu M and 1 mu M -1 mM with a detection limit as low as 16 nM. In addition, it showed excellent selectivity in the presence of various interfering reagents as well as very low cellular toxicity and excellent bio-imaging properties. Overall, the g-CNQDs/PBA fabricated in this study can be a promising candidate for a range of clinical diagnostics and biomedical applications.

引用

页码：36 / 44

页数：9

共 43 条

[1]

[Anonymous], 2016, REV ENDOCR METAB DIS

[2] Facile bulk production of highly blue fluorescent graphitic carbon nitride quantum dots and their application as highly selective and sensitive sensors for the detection of mercuric and iodide ions in aqueous media [J].