Endocytosis of dextran and silan-coated magnetite nanoparticles and the effect of intracellular hyperthermia on human mammary carcinoma cells in vitro

被引：446
作者：
Jordan, A
Scholz, R
Wust, P
Schirra, H
Schiestel, T
Schmidt, H
Felix, R
机构：
[1] Humboldt Univ, Univ Clin Charite, Fac Med, Dept Radiat Oncol WE 07,SFB 273, Berlin, Germany
[2] INM, D-66123 Saarbrucken, Germany
来源：
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 1999年 / 194卷 / 1-3期
关键词：
endocytosis; magnetic fluid hyperthermia; nanoparticles; magnetite; cancer; biomedical application;
D O I：
10.1016/S0304-8853(98)00558-7
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
To obtain more evidence for intracellular magnetic fluid hyperthermia (MFH), endocytosis and hyperthermia efficacy of silan and dextran magnetite was investigated. Differential endocytosis was observed in dependence of nanoparticle and cell type. Clonogenic survival was 3-fold lower after MFH versus waterbath hyperthermia. The selective "remote inactivation" of cancer cells by an AC magnetic field has been demonstrated in vitro. (C) 1999 Elsevier Science B.V. All rights reserved.
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收藏
页码：185 / 196
页数：12
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