Whipple disease: intestinal infiltrating cells exhibit a transcriptional pattern of M2/alternatively activated macrophages

被引：60
作者：
Desnues, B [1 ]
Lepidi, H [1 ]
Raoult, D [1 ]
Mege, JL [1 ]
机构：
[1] Univ Mediterranee, Fac Med, Inst Federat Rech 48, Unite Rickettsies,CNRS,UMR 6020, F-13385 Marseille, France
来源：
JOURNAL OF INFECTIOUS DISEASES | 2005年 / 192卷 / 09期
关键词：
D O I：
10.1086/491745
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Whipple disease (WD) is a rare systemic disease caused by Tropheryma whipplei and is characterized by the presence of foamy macrophages with periodic acid-Schiff - positive inclusions in tissues such as lamina propria. For the first time, we report the gene-expression profile of macrophages in intestinal lesions from a patient with WD. Microarray and real-time polymerase chain reaction revealed that genes encoding CCL18, cathepsins, scavenger receptor, interleukin-10, and lipid metabolites were up-regulated in intestinal lesions. This transcriptional pattern corresponds to that of M2/alternatively activated macrophages. Our results suggest that the T helper 2 response in the intestinal environment may account for the pathophysiological properties of WD.
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收藏
页码：1642 / 1646
页数：5
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