Background Ventricular alternans of repolarization produces serious ventricular arrhythmias in experimental models. The present study investigated the role of alternans of atrial repolarization in patients with atrial fibrillation (AF). Methods and Results Electrophysiological studies were performed in 19 patients without structural heart disease. Monophasic action potentials (MAP) were recorded with 2 Franz catheters during steady state pacing, starting at a cycle length (CL) of 400 ms with subsequent decrements of 10 ms. Duration from the onset of upstroke to 90% repolarization of the MAP were measured. If discordant alternans (DA) was present during pacing, verapamil was administrated, and MAP measurements were repeated. Rapid pacing resulted in concordant alternans to DA in 13 of 19 (68%) patients. AF was initiated after the induction of DA in 8 of 13 patients (p=0.012). Verapamil treatment resulted in a significant decrease in the longest pacing CL at which DA was induced (207 19 vs 178 17 ms, p<0.0001). Conclusions Rapid atrial pacing induced DA and was associated with initiation of AF. Furthermore, induction of DA was suppressed by verapamil. Reducing the spatiotemporal repolarization heterogeneity may be how the calcium-channel blockade prevents initiation of AF.
机构:
Korea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South KoreaKorea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South Korea
Kim, BS
Kim, YH
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Korea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South KoreaKorea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South Korea
Kim, YH
Hwang, GS
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Korea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South KoreaKorea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South Korea
Hwang, GS
Pak, HN
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Korea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South KoreaKorea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South Korea
Pak, HN
Lee, SC
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Korea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South KoreaKorea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South Korea
Lee, SC
Shim, WJ
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Korea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South KoreaKorea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South Korea
Shim, WJ
Oh, DJ
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Korea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South KoreaKorea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South Korea
Oh, DJ
Ro, YM
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Korea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South KoreaKorea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South Korea
机构:
Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Kinebuchi, O
Mitamura, H
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Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Mitamura, H
Shiroshita-Takeshita, A
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Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Shiroshita-Takeshita, A
Kurita, Y
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Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Kurita, Y
Ieda, M
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Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Ieda, M
Ohashi, N
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Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Ohashi, N
Fukuda, Y
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Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Fukuda, Y
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Sato, T
Miyoshi, S
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Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Miyoshi, S
Hara, M
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Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Hara, M
Takatsuki, S
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Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Takatsuki, S
Nagumo, M
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Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Nagumo, M
Ogawa, S
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Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
机构:
Korea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South KoreaKorea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South Korea
Kim, BS
Kim, YH
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Korea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South KoreaKorea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South Korea
Kim, YH
Hwang, GS
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Korea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South KoreaKorea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South Korea
Hwang, GS
Pak, HN
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h-index: 0
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Korea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South KoreaKorea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South Korea
Pak, HN
Lee, SC
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h-index: 0
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Korea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South KoreaKorea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South Korea
Lee, SC
Shim, WJ
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h-index: 0
机构:
Korea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South KoreaKorea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South Korea
Shim, WJ
Oh, DJ
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h-index: 0
机构:
Korea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South KoreaKorea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South Korea
Oh, DJ
Ro, YM
论文数: 0引用数: 0
h-index: 0
机构:
Korea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South KoreaKorea Univ, Med Ctr, Div Cardiol,Dept Med, Sungbuk Ku, Seoul 136705, South Korea
机构:
Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Kinebuchi, O
Mitamura, H
论文数: 0引用数: 0
h-index: 0
机构:
Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Mitamura, H
Shiroshita-Takeshita, A
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机构:
Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Shiroshita-Takeshita, A
Kurita, Y
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h-index: 0
机构:
Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Kurita, Y
Ieda, M
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机构:
Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Ieda, M
Ohashi, N
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机构:
Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Ohashi, N
Fukuda, Y
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Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Fukuda, Y
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Sato, T
Miyoshi, S
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机构:
Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Miyoshi, S
Hara, M
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h-index: 0
机构:
Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Hara, M
Takatsuki, S
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机构:
Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Takatsuki, S
Nagumo, M
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机构:
Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan
Nagumo, M
Ogawa, S
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机构:
Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, Tokyo 1608582, Japan